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- W4241434172 abstract "The synthesis of DNA requires reduced folates. Purine synthesis requires 10-formyltetrahydrofolate (CHO-FH4 )as a methyl donor and 5,10-methylenete-trahydrofolate (CH2-FH4) as carbon donor in the synthesis of thymidine (Fig.1). Methotrexate inhibits dihydrofolate reductase (DHFR)depleting cells of reduced folates, including CHO-FH4 and CH2 -FH4 [1]. Reduced folate depletion does not account for all inhibition of DNA synthesis seen with methotrexate. Methotrexate is metabolized to methotrexate polyglutamates that contribute to cytotoxicity by directly inhibiting the folate dependent enzymes of thymidylate and purine biosynthesis TS, AICAR, GAR" @default.
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- W4241434172 date "2007-06-12" @default.
- W4241434172 modified "2023-09-27" @default.
- W4241434172 title "Antimetabolites" @default.
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- W4241434172 doi "https://doi.org/10.1007/3-7643-7407-1_1" @default.
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