Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241495503> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4241495503 endingPage "1943" @default.
- W4241495503 startingPage "1935" @default.
- W4241495503 abstract "Nicotine is a potent stimulus for the secretion of ACTH, and norepinephrinergic neurons originating in the brainstem are involved. Prior reports using in vivo microdialysis in alert rats have shown that nicotine, administered ip or into the fourth ventricle, stimulated the release of norepinephrine (NE) into the hypothalamic paraventricular nucleus (PVN), the site of neurons containing CRH. In the present studies, rats received an iv infusion of nicotine into the jugular vein on alternate days during their active (dark) phase; therefore, direct correlations between the levels of NE microdialyzed from the PVN and plasma ACTH could be made in each animal. Nicotine administered iv (0.045–0.135 mg/kg) elicited dose-dependent increases in both NE and ACTH (P < 0.01). A significant correlation was found between nicotine-stimulated NE release in the PVN and ACTH secretion (r = 0.91, P < 0.01). To address whether the site(s) of action of nicotine was on presynaptic receptors on NE terminals in the PVN or on receptors on neurons in brainstem regions accessible from the fourth ventricle, the nicotinic cholinergic antagonist, mecamylamine (0.1–4.8 μg), was microinjected directly into the PVN or into the fourth ventricle before nicotine infusion. Fourth-ventricular administration of mecamylamine (1.6 μg) or higher, before iv nicotine (0.09 mg/kg), completely blocked both NE release in the PVN (IC50 = 0.64 μg) and ACTH secretion (IC50 = 0.40 μg) (P < 0.01, compared with vehicle before nicotine), whereas it was ineffective when injected directly into the PVN. The results demonstrate that the nicotinic cholinergic receptors in the brainstem, rather than presynaptic receptors within the PVN itself, mediate nicotine-stimulated PVN NE release and ACTH secretion." @default.
- W4241495503 created "2022-05-12" @default.
- W4241495503 creator A5091841056 @default.
- W4241495503 date "1997-05-01" @default.
- W4241495503 modified "2023-09-27" @default.
- W4241495503 title "Adrenocorticotropin Response and Nicotine-Induced Norepinephrine Secretion in the Rat Paraventricular Nucleus Are Mediated through Brainstem Receptors" @default.
- W4241495503 doi "https://doi.org/10.1210/en.138.5.1935" @default.
- W4241495503 hasPublicationYear "1997" @default.
- W4241495503 type Work @default.
- W4241495503 citedByCount "20" @default.
- W4241495503 countsByYear W42414955032012 @default.
- W4241495503 countsByYear W42414955032013 @default.
- W4241495503 crossrefType "journal-article" @default.
- W4241495503 hasAuthorship W4241495503A5091841056 @default.
- W4241495503 hasBestOaLocation W42414955031 @default.
- W4241495503 hasConcept C105702510 @default.
- W4241495503 hasConcept C126322002 @default.
- W4241495503 hasConcept C134018914 @default.
- W4241495503 hasConcept C170493617 @default.
- W4241495503 hasConcept C185592680 @default.
- W4241495503 hasConcept C188987157 @default.
- W4241495503 hasConcept C2776473159 @default.
- W4241495503 hasConcept C2776880047 @default.
- W4241495503 hasConcept C2777003273 @default.
- W4241495503 hasConcept C2778468602 @default.
- W4241495503 hasConcept C2779547902 @default.
- W4241495503 hasConcept C529278444 @default.
- W4241495503 hasConcept C71924100 @default.
- W4241495503 hasConcept C86803240 @default.
- W4241495503 hasConceptScore W4241495503C105702510 @default.
- W4241495503 hasConceptScore W4241495503C126322002 @default.
- W4241495503 hasConceptScore W4241495503C134018914 @default.
- W4241495503 hasConceptScore W4241495503C170493617 @default.
- W4241495503 hasConceptScore W4241495503C185592680 @default.
- W4241495503 hasConceptScore W4241495503C188987157 @default.
- W4241495503 hasConceptScore W4241495503C2776473159 @default.
- W4241495503 hasConceptScore W4241495503C2776880047 @default.
- W4241495503 hasConceptScore W4241495503C2777003273 @default.
- W4241495503 hasConceptScore W4241495503C2778468602 @default.
- W4241495503 hasConceptScore W4241495503C2779547902 @default.
- W4241495503 hasConceptScore W4241495503C529278444 @default.
- W4241495503 hasConceptScore W4241495503C71924100 @default.
- W4241495503 hasConceptScore W4241495503C86803240 @default.
- W4241495503 hasIssue "5" @default.
- W4241495503 hasLocation W42414955031 @default.
- W4241495503 hasOpenAccess W4241495503 @default.
- W4241495503 hasPrimaryLocation W42414955031 @default.
- W4241495503 hasRelatedWork W1889309137 @default.
- W4241495503 hasRelatedWork W1993175254 @default.
- W4241495503 hasRelatedWork W2021078633 @default.
- W4241495503 hasRelatedWork W2034583712 @default.
- W4241495503 hasRelatedWork W2051488242 @default.
- W4241495503 hasRelatedWork W2057609658 @default.
- W4241495503 hasRelatedWork W2075883892 @default.
- W4241495503 hasRelatedWork W2166704781 @default.
- W4241495503 hasRelatedWork W2414846389 @default.
- W4241495503 hasRelatedWork W2773858965 @default.
- W4241495503 hasVolume "138" @default.
- W4241495503 isParatext "false" @default.
- W4241495503 isRetracted "false" @default.
- W4241495503 workType "article" @default.