FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241502238> ?p ?o ?g. }

• W4241502238 abstract "Abstract Background We aimed to evaluate the safety and efficacy of TS-1 adjuvant chemotherapy in Taiwanese patients with gastric cancer. Methods We included in this study patients with locally advanced gastric cancer who received adjuvant TS-1 or 5-fluorouracil chemotherapy after curative surgery and extended lymph node dissection between 1 June 2008 and 31 December 2012 at Chang Gung Memorial Hospital. Patient characteristics, tumor features, safety profiles and compliance with TS-1 treatment were retrospectively analyzed from medical charts. Results Forty patients received adjuvant chemotherapy with TS-1 and 193 with 5-fluorouracil within the study period. The 1- and 2-year overall survival rates were 90.6% and 87% in the TS-1 group and 95.4% and 86.8% in the 5-fluorouracil group ( P = 0.34). The 1- and 2-year disease-free survival rates were 90.6% and 74.7% in the TS-1 group and 88% and 75.7% in the 5-fluorouracil group ( P = 0.66). In the TS-1 group, tumor recurrence was more frequent in those with >15 metastatic lymph nodes than ≤15. Overall, 78.9%, 74.3%, 62.1% and 56% of patients underwent TS-1 treatment for at least 3, 6, 9 and 12 months, respectively. The most common adverse events of TS-1 were skin hyperpigmentation (55%), diarrhea (27.5%), dizziness (27.5%) and leucopenia (20%). Severe adverse events (SAEs; grade III or IV toxicity) were diarrhea (7.5%), stomatitis (7.5%), leukopenia (5%), vomiting (2.5%), anorexia (2.5%) and dizziness (2.5%). Patients who underwent total gastrectomy had a significantly greater risk of TS-1-related SAEs than patients who underwent subtotal gastrectomy (40% versus 8%, P = 0.014). Conclusions The incidence of SAEs during TS-1 therapy was more common in Taiwanese patients with gastric cancer who underwent total gastrectomy compared with those who underwent subtotal gastrectomy. Clinicians must be aware of and able to manage these SAEs to maximize patient compliance with adjuvant TS-1." @default.
• W4241502238 created "2022-05-12" @default.
• W4241502238 creator A5000986526 @default.
• W4241502238 creator A5005392866 @default.
• W4241502238 creator A5011994790 @default.
• W4241502238 creator A5013065715 @default.
• W4241502238 creator A5014397451 @default.
• W4241502238 creator A5024024448 @default.
• W4241502238 creator A5027932918 @default.
• W4241502238 creator A5053209984 @default.
• W4241502238 creator A5088734348 @default.
• W4241502238 date "2013-11-01" @default.
• W4241502238 modified "2023-09-30" @default.
• W4241502238 title "Total gastrectomy increases the incidence of grade III and IV toxicities in patients with gastric cancer receiving adjuvant TS-1 treatment" @default.
• W4241502238 cites W12636511 @default.
• W4241502238 cites W1787252376 @default.
• W4241502238 cites W1962875322 @default.
• W4241502238 cites W1970726611 @default.
• W4241502238 cites W1971485401 @default.
• W4241502238 cites W1990756166 @default.
• W4241502238 cites W1995705474 @default.
• W4241502238 cites W2027154886 @default.
• W4241502238 cites W2027836330 @default.
• W4241502238 cites W2034928508 @default.
• W4241502238 cites W2038763098 @default.
• W4241502238 cites W2055695670 @default.
• W4241502238 cites W2065887320 @default.
• W4241502238 cites W2078090242 @default.
• W4241502238 cites W2085434297 @default.
• W4241502238 cites W2098719201 @default.
• W4241502238 cites W2100642935 @default.
• W4241502238 cites W2102991666 @default.
• W4241502238 cites W2106787323 @default.
• W4241502238 cites W2110263577 @default.
• W4241502238 cites W2113947048 @default.
• W4241502238 cites W2133593152 @default.
• W4241502238 cites W2137991416 @default.
• W4241502238 cites W2145390243 @default.
• W4241502238 cites W2150291338 @default.
• W4241502238 cites W2152225451 @default.
• W4241502238 cites W2152256906 @default.
• W4241502238 cites W2229238935 @default.
• W4241502238 cites W2248925270 @default.
• W4241502238 cites W4239180165 @default.
• W4241502238 cites W4255290073 @default.
• W4241502238 doi "https://doi.org/10.1186/1477-7819-11-287" @default.
• W4241502238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24180462" @default.
• W4241502238 hasPublicationYear "2013" @default.
• W4241502238 type Work @default.
• W4241502238 citedByCount "9" @default.
• W4241502238 countsByYear W42415022382013 @default.
• W4241502238 countsByYear W42415022382015 @default.
• W4241502238 countsByYear W42415022382018 @default.
• W4241502238 countsByYear W42415022382020 @default.
• W4241502238 countsByYear W42415022382021 @default.
• W4241502238 countsByYear W42415022382023 @default.
• W4241502238 crossrefType "journal-article" @default.
• W4241502238 hasAuthorship W4241502238A5000986526 @default.
• W4241502238 hasAuthorship W4241502238A5005392866 @default.
• W4241502238 hasAuthorship W4241502238A5011994790 @default.
• W4241502238 hasAuthorship W4241502238A5013065715 @default.
• W4241502238 hasAuthorship W4241502238A5014397451 @default.
• W4241502238 hasAuthorship W4241502238A5024024448 @default.
• W4241502238 hasAuthorship W4241502238A5027932918 @default.
• W4241502238 hasAuthorship W4241502238A5053209984 @default.
• W4241502238 hasAuthorship W4241502238A5088734348 @default.
• W4241502238 hasBestOaLocation W42415022381 @default.
• W4241502238 hasConcept C121608353 @default.
• W4241502238 hasConcept C126322002 @default.
• W4241502238 hasConcept C141071460 @default.
• W4241502238 hasConcept C197934379 @default.
• W4241502238 hasConcept C2776694085 @default.
• W4241502238 hasConcept C2778496288 @default.
• W4241502238 hasConcept C2779802037 @default.
• W4241502238 hasConcept C2780140570 @default.
• W4241502238 hasConcept C2780456651 @default.
• W4241502238 hasConcept C2780470880 @default.
• W4241502238 hasConcept C2780580376 @default.
• W4241502238 hasConcept C2780852908 @default.
• W4241502238 hasConcept C2780873365 @default.
• W4241502238 hasConcept C71924100 @default.
• W4241502238 hasConcept C90924648 @default.
• W4241502238 hasConceptScore W4241502238C121608353 @default.
• W4241502238 hasConceptScore W4241502238C126322002 @default.
• W4241502238 hasConceptScore W4241502238C141071460 @default.
• W4241502238 hasConceptScore W4241502238C197934379 @default.
• W4241502238 hasConceptScore W4241502238C2776694085 @default.
• W4241502238 hasConceptScore W4241502238C2778496288 @default.
• W4241502238 hasConceptScore W4241502238C2779802037 @default.
• W4241502238 hasConceptScore W4241502238C2780140570 @default.
• W4241502238 hasConceptScore W4241502238C2780456651 @default.
• W4241502238 hasConceptScore W4241502238C2780470880 @default.
• W4241502238 hasConceptScore W4241502238C2780580376 @default.
• W4241502238 hasConceptScore W4241502238C2780852908 @default.
• W4241502238 hasConceptScore W4241502238C2780873365 @default.
• W4241502238 hasConceptScore W4241502238C71924100 @default.
• W4241502238 hasConceptScore W4241502238C90924648 @default.
• W4241502238 hasIssue "1" @default.
• W4241502238 hasLocation W42415022381 @default.
• W4241502238 hasLocation W42415022382 @default.

• next