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- W4241521347 abstract "Frog (Rana catesbeiana) rod outer segment membrane contains cyclic GMP phosphodiesterase (EC 3.1.4.1). Irradiation of dark-adapted rod outer segment membrane increased the enzyme activity by 5–20-fold in the presence of GTP. The phosphodiesterase in rod outer segment membrane is also activated by mixing a photo-product of 11-cis (regenerated), 9-cis or 7-cis rhodopsin which is stable at 0°C. However, neither opsin in the membrane nor all-trans retinal activates the enzyme. The phosphodiesterase in rod outer segment membrane is also activated by irradiation at −4°C. Thus, we conclude that the phosphodiesterase is activated by a common photolysis intermediate of these rhodopsin isomers, perhaps before metarhodopsin II decays." @default.
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- W4241521347 date "1981-07-01" @default.
- W4241521347 modified "2023-10-17" @default.
- W4241521347 title "Activation of phosphodiesterase in frog rod outer segment by an intermediate of rhodopsin photolysis. II" @default.
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- W4241521347 doi "https://doi.org/10.1016/0304-4165(81)90226-9" @default.
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