Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241551147> ?p ?o ?g. }
- W4241551147 endingPage "113" @default.
- W4241551147 startingPage "105" @default.
- W4241551147 abstract "A rapid, sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method was developed for the simultaneous assay of dextromethorphan and its metabolites in tissue culture medium and its intestinal metabolism studied with the rat everted gut sac model. The method was validated in the concentration range of 0.1-2.5 microM (27.1 ng/mL-0.677 microg/mL) for dextromethorphan and 0.005-0.5 microM for dextrorphan and 3-methoxymorphinan (1.28 ng/mL-0.128 microg/mL) and 3-hydroxymorphinan (1.22 ng/mL-0.122 microg/mL). The limits of quantification (LOQ) were 0.0025 microM (12.5 fmoles, 3.4 pg, 5 microL injected) for dextromethorphan; 0.0025 microM for dextrorphan, 3-methoxymorphinan (24.9 fmoles, 6.4 pg injected), and 3-hydroxymorphinan (25.1 fmoles, 6.1 pg injected) with 10 microL injected. The detection of dextrorphan and 3-methoxymorphinan showed that both the P450 isoforms CYP3A and 2D were active in the intestinal mucosa and metabolised dextromethorphan during its passage across the mucosa." @default.
- W4241551147 created "2022-05-12" @default.
- W4241551147 creator A5002188653 @default.
- W4241551147 creator A5005400732 @default.
- W4241551147 creator A5010285605 @default.
- W4241551147 creator A5034870018 @default.
- W4241551147 creator A5040872398 @default.
- W4241551147 creator A5054310827 @default.
- W4241551147 creator A5075006471 @default.
- W4241551147 date "2005-05-01" @default.
- W4241551147 modified "2023-09-30" @default.
- W4241551147 title "Validation of a liquid chromatography–mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs" @default.
- W4241551147 cites W1573664132 @default.
- W4241551147 cites W1972083277 @default.
- W4241551147 cites W1981336339 @default.
- W4241551147 cites W1987731308 @default.
- W4241551147 cites W1988665133 @default.
- W4241551147 cites W1995130586 @default.
- W4241551147 cites W2006371139 @default.
- W4241551147 cites W2015336605 @default.
- W4241551147 cites W2023777641 @default.
- W4241551147 cites W2025178589 @default.
- W4241551147 cites W2032811036 @default.
- W4241551147 cites W2038368894 @default.
- W4241551147 cites W2039657546 @default.
- W4241551147 cites W2049172583 @default.
- W4241551147 cites W2055417905 @default.
- W4241551147 cites W2055576047 @default.
- W4241551147 cites W2057763305 @default.
- W4241551147 cites W2063222002 @default.
- W4241551147 cites W2065921364 @default.
- W4241551147 cites W2069188554 @default.
- W4241551147 cites W2071542949 @default.
- W4241551147 cites W2073675641 @default.
- W4241551147 cites W2077229986 @default.
- W4241551147 cites W2082019351 @default.
- W4241551147 cites W2085815144 @default.
- W4241551147 cites W2091415048 @default.
- W4241551147 cites W2091788881 @default.
- W4241551147 cites W2096196298 @default.
- W4241551147 cites W2107567029 @default.
- W4241551147 cites W2109480116 @default.
- W4241551147 cites W2143310401 @default.
- W4241551147 cites W4254333536 @default.
- W4241551147 cites W4323284006 @default.
- W4241551147 doi "https://doi.org/10.1016/j.jchromb.2005.01.036" @default.
- W4241551147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15797528" @default.
- W4241551147 hasPublicationYear "2005" @default.
- W4241551147 type Work @default.
- W4241551147 citedByCount "17" @default.
- W4241551147 countsByYear W42415511472014 @default.
- W4241551147 countsByYear W42415511472023 @default.
- W4241551147 crossrefType "journal-article" @default.
- W4241551147 hasAuthorship W4241551147A5002188653 @default.
- W4241551147 hasAuthorship W4241551147A5005400732 @default.
- W4241551147 hasAuthorship W4241551147A5010285605 @default.
- W4241551147 hasAuthorship W4241551147A5034870018 @default.
- W4241551147 hasAuthorship W4241551147A5040872398 @default.
- W4241551147 hasAuthorship W4241551147A5054310827 @default.
- W4241551147 hasAuthorship W4241551147A5075006471 @default.
- W4241551147 hasConcept C162356407 @default.
- W4241551147 hasConcept C185592680 @default.
- W4241551147 hasConcept C2777477808 @default.
- W4241551147 hasConcept C2779591118 @default.
- W4241551147 hasConcept C2781245242 @default.
- W4241551147 hasConcept C43617362 @default.
- W4241551147 hasConcept C55493867 @default.
- W4241551147 hasConcept C62231903 @default.
- W4241551147 hasConcept C64489805 @default.
- W4241551147 hasConcept C71924100 @default.
- W4241551147 hasConcept C95986675 @default.
- W4241551147 hasConcept C98274493 @default.
- W4241551147 hasConceptScore W4241551147C162356407 @default.
- W4241551147 hasConceptScore W4241551147C185592680 @default.
- W4241551147 hasConceptScore W4241551147C2777477808 @default.
- W4241551147 hasConceptScore W4241551147C2779591118 @default.
- W4241551147 hasConceptScore W4241551147C2781245242 @default.
- W4241551147 hasConceptScore W4241551147C43617362 @default.
- W4241551147 hasConceptScore W4241551147C55493867 @default.
- W4241551147 hasConceptScore W4241551147C62231903 @default.
- W4241551147 hasConceptScore W4241551147C64489805 @default.
- W4241551147 hasConceptScore W4241551147C71924100 @default.
- W4241551147 hasConceptScore W4241551147C95986675 @default.
- W4241551147 hasConceptScore W4241551147C98274493 @default.
- W4241551147 hasIssue "1" @default.
- W4241551147 hasLocation W42415511471 @default.
- W4241551147 hasLocation W42415511472 @default.
- W4241551147 hasOpenAccess W4241551147 @default.
- W4241551147 hasPrimaryLocation W42415511471 @default.
- W4241551147 hasRelatedWork W2003174742 @default.
- W4241551147 hasRelatedWork W2006371139 @default.
- W4241551147 hasRelatedWork W2022610105 @default.
- W4241551147 hasRelatedWork W2045048867 @default.
- W4241551147 hasRelatedWork W2057763305 @default.
- W4241551147 hasRelatedWork W2082409779 @default.
- W4241551147 hasRelatedWork W2121102924 @default.
- W4241551147 hasRelatedWork W2122617033 @default.
- W4241551147 hasRelatedWork W2167325319 @default.