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- W4241608438 abstract "All known membrane-associated CD44 isoforms have five constant exons at the N-terminus followed by 10 alternatively spliced exons, two constant membrane-proximal coding exons, a constant transmembrane-coding exon, and two potentially alternatively spliced exons coding for cytoplasmic domains. The great variability in splicing leads to at least 18 different CD44 isoforms. CD44 has been shown to bind to hyaluronic acid, heparin sulfate, collagen type I and VI, fibronectin, and several cytoskeleton proteins. This chapter presents a study in which CD44–/– mice backcrossed into C57BL/6 were born healthy at the expected Mendelian ratio and developed normally. No gross deficits in neurological function or behavior were apparent. CD44–/– mice did not show a significant reduction in the total number of white blood cells or granulocytes in the peripheral blood. There was no significant difference in the number of hematopoietic progenitor cells in the fetal liver. There was normal engraftment of CD44-deficient fetal liver cells into the spleen of wildtype recipients. The results of this study suggest that, in fibroblasts, the interaction with the CD44 ligands or cytokines might alter the interaction between tumor cells and surrounding stroma and result in an inhibitory effect on tumor growth." @default.
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- W4241608438 date "1998-01-01" @default.
- W4241608438 modified "2023-09-27" @default.
- W4241608438 title "CD44" @default.
- W4241608438 doi "https://doi.org/10.1016/b978-012466044-1/50096-x" @default.
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