Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241716468> ?p ?o ?g. }
- W4241716468 endingPage "201" @default.
- W4241716468 startingPage "195" @default.
- W4241716468 abstract "Ursodeoxycholic acid (UDCA)-producing bacteria are of clinical and industrial interest due to the multiple beneficial effects of this bile acid on human health. UDCA is the 7β-OH epimer of the primary (i.e. synthesized by the liver) bile acid chenodeoxycholic acid (CDCA). Epimerization proceeds in two subsequent and reversible steps, catalysed by a 7α- and a 7β-hydroxysteroid dehydrogenase (7α- and 7β-HSDH), with 7oxo-lithocholic acid (7oxo-LCA) as the intermediate product. The aim of this study was to test the 7α- and 7β-HSDH activities of anaerobic whole cell cultures of a number of lactic acid bacteria and human intestinal isolates, using CDCA, UDCA and 7oxo-LCA as the substrates. Among 140 strains tested, 21 exhibited at least one of both 7-HSDH activities. 7α-HSDH activity was detected in six strains, 7β-HSDH in nine strains, and both activities in six other strains. All active strains were isolated from normal human and infant faeces. They belonged to the genera Clostridium, Eubacterium and Ruminococcus, whereas no strain of Lactobacillus, Bifidobacterium or Streptococcus was found to be active under our study conditions. The present study therefore revealed, for the first time, a number of normal human intestinal isolates supporting the epimerization of CDCA to UDCA, and further extended our knowledge of those intestinal bacteria which are responsible for 7α- or 7β-HSDH activity. Key words: screening, bile acids, epimerization, intestinal microflora, lactic acid bacteria, probiotics." @default.
- W4241716468 created "2022-05-12" @default.
- W4241716468 creator A5000811719 @default.
- W4241716468 creator A5028388032 @default.
- W4241716468 creator A5041917681 @default.
- W4241716468 creator A5061807468 @default.
- W4241716468 creator A5066124317 @default.
- W4241716468 creator A5073263495 @default.
- W4241716468 creator A5079415533 @default.
- W4241716468 date "2004-12-01" @default.
- W4241716468 modified "2023-09-25" @default.
- W4241716468 title "Isolates from normal human intestinal flora but not lactic acid bacteria exhibit 7α- and 7β-hydroxysteroid dehydrogenase activities" @default.
- W4241716468 cites W116861903 @default.
- W4241716468 cites W1489924817 @default.
- W4241716468 cites W1531658136 @default.
- W4241716468 cites W1595270481 @default.
- W4241716468 cites W1855871810 @default.
- W4241716468 cites W1935149946 @default.
- W4241716468 cites W1977172878 @default.
- W4241716468 cites W1997136405 @default.
- W4241716468 cites W2015372020 @default.
- W4241716468 cites W2021896492 @default.
- W4241716468 cites W2029308184 @default.
- W4241716468 cites W2055725501 @default.
- W4241716468 cites W2063813012 @default.
- W4241716468 cites W2074739906 @default.
- W4241716468 cites W2075256544 @default.
- W4241716468 cites W2124677452 @default.
- W4241716468 cites W2185358847 @default.
- W4241716468 cites W2224078765 @default.
- W4241716468 cites W2342479904 @default.
- W4241716468 cites W4241596094 @default.
- W4241716468 doi "https://doi.org/10.1080/08910600410033393" @default.
- W4241716468 hasPublicationYear "2004" @default.
- W4241716468 type Work @default.
- W4241716468 citedByCount "16" @default.
- W4241716468 countsByYear W42417164682013 @default.
- W4241716468 countsByYear W42417164682016 @default.
- W4241716468 countsByYear W42417164682017 @default.
- W4241716468 countsByYear W42417164682018 @default.
- W4241716468 countsByYear W42417164682019 @default.
- W4241716468 countsByYear W42417164682020 @default.
- W4241716468 countsByYear W42417164682022 @default.
- W4241716468 crossrefType "journal-article" @default.
- W4241716468 hasAuthorship W4241716468A5000811719 @default.
- W4241716468 hasAuthorship W4241716468A5028388032 @default.
- W4241716468 hasAuthorship W4241716468A5041917681 @default.
- W4241716468 hasAuthorship W4241716468A5061807468 @default.
- W4241716468 hasAuthorship W4241716468A5066124317 @default.
- W4241716468 hasAuthorship W4241716468A5073263495 @default.
- W4241716468 hasAuthorship W4241716468A5079415533 @default.
- W4241716468 hasBestOaLocation W42417164681 @default.
- W4241716468 hasConcept C181199279 @default.
- W4241716468 hasConcept C2775900799 @default.
- W4241716468 hasConcept C2775920511 @default.
- W4241716468 hasConcept C2776317432 @default.
- W4241716468 hasConcept C2779399885 @default.
- W4241716468 hasConcept C2779930906 @default.
- W4241716468 hasConcept C2780027724 @default.
- W4241716468 hasConcept C2780092757 @default.
- W4241716468 hasConcept C2780206646 @default.
- W4241716468 hasConcept C2780305828 @default.
- W4241716468 hasConcept C2780420665 @default.
- W4241716468 hasConcept C2780965833 @default.
- W4241716468 hasConcept C2781067048 @default.
- W4241716468 hasConcept C2781089062 @default.
- W4241716468 hasConcept C2992397963 @default.
- W4241716468 hasConcept C523546767 @default.
- W4241716468 hasConcept C54355233 @default.
- W4241716468 hasConcept C55493867 @default.
- W4241716468 hasConcept C61716771 @default.
- W4241716468 hasConcept C86803240 @default.
- W4241716468 hasConcept C89423630 @default.
- W4241716468 hasConceptScore W4241716468C181199279 @default.
- W4241716468 hasConceptScore W4241716468C2775900799 @default.
- W4241716468 hasConceptScore W4241716468C2775920511 @default.
- W4241716468 hasConceptScore W4241716468C2776317432 @default.
- W4241716468 hasConceptScore W4241716468C2779399885 @default.
- W4241716468 hasConceptScore W4241716468C2779930906 @default.
- W4241716468 hasConceptScore W4241716468C2780027724 @default.
- W4241716468 hasConceptScore W4241716468C2780092757 @default.
- W4241716468 hasConceptScore W4241716468C2780206646 @default.
- W4241716468 hasConceptScore W4241716468C2780305828 @default.
- W4241716468 hasConceptScore W4241716468C2780420665 @default.
- W4241716468 hasConceptScore W4241716468C2780965833 @default.
- W4241716468 hasConceptScore W4241716468C2781067048 @default.
- W4241716468 hasConceptScore W4241716468C2781089062 @default.
- W4241716468 hasConceptScore W4241716468C2992397963 @default.
- W4241716468 hasConceptScore W4241716468C523546767 @default.
- W4241716468 hasConceptScore W4241716468C54355233 @default.
- W4241716468 hasConceptScore W4241716468C55493867 @default.
- W4241716468 hasConceptScore W4241716468C61716771 @default.
- W4241716468 hasConceptScore W4241716468C86803240 @default.
- W4241716468 hasConceptScore W4241716468C89423630 @default.
- W4241716468 hasIssue "4" @default.
- W4241716468 hasLocation W42417164681 @default.
- W4241716468 hasLocation W42417164682 @default.
- W4241716468 hasLocation W42417164683 @default.