Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241786875> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4241786875 abstract "Abstract Background: Panax notoginseng triol saponins (PTS) has been used clinically for ischemic stroke therapy (IST) by potential anti-platelet aggregation and neuro-protective in China for more than sixteen years, but its mechanisms are still unclear. In this study, anti-platelet aggregation related protein analysis and computer simulations of drug-protein binding interactions were performed for exploring mechanism of PTS against ischemic stroke by ischemia reperfusion model. Methods: Three doses of PTS were administered orally in middle cerebral artery occlusion (MCAO) model rats; Panax notoginseng total saponins (PNS) and the combination of PTS and aspirin were chosen as comparison. The cerebral infarct size and water content in brain tissue, histomorphological observation, related factors and platelet receptor expression in serum, as well as binding affinity of PTS and platelet adhesion receptor were detected to evaluate therapeutic effect and explore possible mechanisms of anti-platelet aggregation. Results: Compared with PNS, PTS showed stronger and more extensive anti-platelet aggregation effect on MCAO model rats. The combination of PTS and aspirin might reduce the gastrointestinal adverse reactions by regulating TXA 2 /PGI 2 ratio. However, PTS could reduce the chance of VWF-mediated platelet adhesion to damaged vascular endothelium, and thus enhance the probability of anti-platelet aggregation and anti-thrombosis under pathological conditions. Conclusion: Our results showed that GP1BA was closely related with anti-platelet aggregation action of PTS, which provided new scientific evidences for its clinical application." @default.
- W4241786875 created "2022-05-12" @default.
- W4241786875 creator A5002847748 @default.
- W4241786875 creator A5006007711 @default.
- W4241786875 creator A5008695663 @default.
- W4241786875 creator A5017227635 @default.
- W4241786875 creator A5018569451 @default.
- W4241786875 creator A5024025818 @default.
- W4241786875 creator A5024122309 @default.
- W4241786875 creator A5037902208 @default.
- W4241786875 creator A5062716491 @default.
- W4241786875 creator A5067189270 @default.
- W4241786875 date "2020-08-13" @default.
- W4241786875 modified "2023-10-16" @default.
- W4241786875 title "Anti-Platelet Aggregation of Panax Notoginseng Triol Saponins by regulating GP1BA for Ischemic Stroke Therapy" @default.
- W4241786875 doi "https://doi.org/10.21203/rs.3.rs-55926/v1" @default.
- W4241786875 hasPublicationYear "2020" @default.
- W4241786875 type Work @default.
- W4241786875 citedByCount "0" @default.
- W4241786875 crossrefType "posted-content" @default.
- W4241786875 hasAuthorship W4241786875A5002847748 @default.
- W4241786875 hasAuthorship W4241786875A5006007711 @default.
- W4241786875 hasAuthorship W4241786875A5008695663 @default.
- W4241786875 hasAuthorship W4241786875A5017227635 @default.
- W4241786875 hasAuthorship W4241786875A5018569451 @default.
- W4241786875 hasAuthorship W4241786875A5024025818 @default.
- W4241786875 hasAuthorship W4241786875A5024122309 @default.
- W4241786875 hasAuthorship W4241786875A5037902208 @default.
- W4241786875 hasAuthorship W4241786875A5062716491 @default.
- W4241786875 hasAuthorship W4241786875A5067189270 @default.
- W4241786875 hasBestOaLocation W42417868751 @default.
- W4241786875 hasConcept C126322002 @default.
- W4241786875 hasConcept C127413603 @default.
- W4241786875 hasConcept C142724271 @default.
- W4241786875 hasConcept C204787440 @default.
- W4241786875 hasConcept C2777628954 @default.
- W4241786875 hasConcept C2780645631 @default.
- W4241786875 hasConcept C2781212864 @default.
- W4241786875 hasConcept C2993802102 @default.
- W4241786875 hasConcept C3018697912 @default.
- W4241786875 hasConcept C3020199598 @default.
- W4241786875 hasConcept C541997718 @default.
- W4241786875 hasConcept C71924100 @default.
- W4241786875 hasConcept C78519656 @default.
- W4241786875 hasConcept C89560881 @default.
- W4241786875 hasConcept C98274493 @default.
- W4241786875 hasConceptScore W4241786875C126322002 @default.
- W4241786875 hasConceptScore W4241786875C127413603 @default.
- W4241786875 hasConceptScore W4241786875C142724271 @default.
- W4241786875 hasConceptScore W4241786875C204787440 @default.
- W4241786875 hasConceptScore W4241786875C2777628954 @default.
- W4241786875 hasConceptScore W4241786875C2780645631 @default.
- W4241786875 hasConceptScore W4241786875C2781212864 @default.
- W4241786875 hasConceptScore W4241786875C2993802102 @default.
- W4241786875 hasConceptScore W4241786875C3018697912 @default.
- W4241786875 hasConceptScore W4241786875C3020199598 @default.
- W4241786875 hasConceptScore W4241786875C541997718 @default.
- W4241786875 hasConceptScore W4241786875C71924100 @default.
- W4241786875 hasConceptScore W4241786875C78519656 @default.
- W4241786875 hasConceptScore W4241786875C89560881 @default.
- W4241786875 hasConceptScore W4241786875C98274493 @default.
- W4241786875 hasLocation W42417868751 @default.
- W4241786875 hasLocation W42417868752 @default.
- W4241786875 hasOpenAccess W4241786875 @default.
- W4241786875 hasPrimaryLocation W42417868751 @default.
- W4241786875 hasRelatedWork W12695969 @default.
- W4241786875 hasRelatedWork W20019967 @default.
- W4241786875 hasRelatedWork W2651279 @default.
- W4241786875 hasRelatedWork W3621267 @default.
- W4241786875 hasRelatedWork W7836624 @default.
- W4241786875 hasRelatedWork W890575 @default.
- W4241786875 hasRelatedWork W1565332 @default.
- W4241786875 hasRelatedWork W1832865 @default.
- W4241786875 hasRelatedWork W1951136 @default.
- W4241786875 hasRelatedWork W3005691 @default.
- W4241786875 isParatext "false" @default.
- W4241786875 isRetracted "false" @default.
- W4241786875 workType "article" @default.