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- W4241813879 abstract "Abstract Skin plays a crucial role in the interaction with the surrounding atmosphere and covers the external body. Skin loss remains one of the most evident problems in the treatment of various clinical cases including burned patients, diabetic foot ulcers, venous leg ulcers, and wounds. Loss of large skin areas is incompatible with sustained life. With the recent advancement of skin engineering, scientists currently seek a universal skin product. They aim to achieve unlimited production of anti‐rejection skin. Skin substitute materials may be able to stimulate regeneration rather than repair, and tissue‐engineered skin may match the quality of split‐skin autografts, the present gold standard. Although scientific and technological advances have contributed to the development of skin substitutes, continued research has the potential to dramatically alter the field of medicine. Improvement of skin alternatives will result from inclusion of additional cell types and from modifications of culture media and scaffolds. The introduction of specific design modifications to tissue‐engineered skin is important because the addition of such features will expand the use of skin products beyond those of healing wounds. For example, tissue‐engineered skin could be used to treat a variety of diseases by delivering growth factors or other therapeutic agents. Successful steps in this field have already been taken; it is possible to transfect keratinocytes with adenoviruses or retroviruses that can carry genes of interest." @default.
- W4241813879 created "2022-05-12" @default.
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- W4241813879 date "2006-04-14" @default.
- W4241813879 modified "2023-10-12" @default.
- W4241813879 title "Skin" @default.
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- W4241813879 doi "https://doi.org/10.1002/9780471740360.ebs1094" @default.
- W4241813879 hasPublicationYear "2006" @default.
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