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- W4241937863 abstract "Thank you for your query regarding the association between calcium supplementation and anemia in our recent analysis of the Women's Health Initiative Observational Study (1Thomson C.A. Stanaway J.D. Neuhouser M.L. Snetselaar L.G. Stefanick M.L. Arendell L. Chen Z. Nutrient intake and anemia risk in the Women's Health Initiative Observational Study.J Am Diet Assoc. 2011; 111: 532-541Google Scholar). As you noted and was discussed in the manuscript, iron deficiency that is a result of inadequate dietary iron results in enhanced iron bioavailability from iron-rich foods. We were not able to discern the exact cause of low hemoglobin in the study sample. However, low iron intake was likely associated with low iron status and was a contributing factor in the low hemoglobin values demonstrated, independent of the enhanced bioavailability of iron from iron-rich foods. Importantly, your assessment that calcium supplementation may be contributing to iron-deficiency anemia related to competing absorption of like-charged minerals such as calcium and iron is relevant and, thus, we have completed further analysis to evaluate this in more detail. We found that 56.9% of those with baseline anemia used calcium supplements compared to 60.3% of those without anemia. Similar percentages were demonstrated for incident (58.3% vs 61.7%) and persistent (51.7% vs 61.7%) anemia, suggesting calcium supplementation was less frequently reported by women with anemia (Table 1). Furthermore, the multiple logistic regression analysis with anemia as the outcome and baseline calcium as the predictor showed no significant risk for incident or persistent anemia in relation to baseline calcium supplementation in the women of the Women's Health Initiative Observational Study.TableAssociation between anemia and baseline calcium supplementation in the Women's Health Initiative Observational StudyORaOR=odds ratio.bAdjusted for ethnicity, calcium supplementation by ethnicity interaction, age (10-year intervals), income, smoking, body mass index, and calcium by ethnicity interaction term.95% CIcCI=confidence interval.P valueIncident anemia (n=52,671)1.090.99, 1.200.76Persistent anemia (n=51,469)0.970.84, 1.110.64a OR=odds ratio.b Adjusted for ethnicity, calcium supplementation by ethnicity interaction, age (10-year intervals), income, smoking, body mass index, and calcium by ethnicity interaction term.c CI=confidence interval. Open table in a new tab Is Anemia in WHI-OS Related to Calcium Supplement Use?Journal of the American Dietetic AssociationVol. 111Issue 10PreviewI am writing with a question on the April 2011 Journal article “Nutrient Intake and Anemia Risk in the Women's Health Initiative Observational Study” (1). Full-Text PDF" @default.
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- W4241937863 date "2011-10-01" @default.
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- W4241937863 title "Author's Response" @default.
- W4241937863 doi "https://doi.org/10.1016/j.jada.2011.08.020" @default.
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