Matches in SemOpenAlex for { <https://semopenalex.org/work/W4241964037> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4241964037 abstract "Abstract Background: Hypoxic pulmonary hypertension (HPH) is a common type of pulmonary hypertension. Alveolar epithelial cells (AECs) are the first to perceive hypoxia of alveolar, however, the role of AECs in HPH remain unclear. HPH is characterized by pulmonary vascular remodeling and constriction. The present study was to whether AECs was involved in pulmonary vascular remodeling and constriction. Methods: Rat HPH models were built and pulmonary artery smooth cells (PASMCs) and AECs were treatment with hypoxia. Hemodynamic and morphological indicators were measured in samples from rat HPH models. Superoxide dismutase 2 (SOD2), catalase (CAT) and reactive oxygen species (ROS) were detected in AECs or AECs culture medium. To find out the effect of AECs on pulmonary vascular remodeling and constriction, AECs and PASMCs were co-cultured under hypoxia, PASMCs and isolated pulmonary artery (PA) were treatment with AECs hypoxic culture medium. To explore the mechanism of AECs on pulmonary vascular remodeling and constriction, ROS inhibitor N-acetylcysteine (NAC) was used. Results: In vivo, hypoxia resulted in elevation in pulmonary vascular remodeling and pressure, but had no effect on non-pulmonary vascular. In vitro, hypoxia caused an imbalance of superoxide dismutase 2 (SOD2) and catalase (CAT) and an increase of reactive oxygen species (ROS) in AECs, as well as an increase of hydrogen peroxide (H 2 O 2 ) in AECs culture medium. Also, AECs led to pulmonary artery smooth cells (PASMCs) proliferation under hypoxia by co-culture or substituting culture medium. AECs hypoxic culture medium enhanced the constriction of isolated pulmonary artery (PA). Further, these responses were abrogated by ROS inhibitor N-acetylcysteine (NAC). Conclusion: The findings of present study demonstrated that AECs involved in pulmonary vascular remodeling and constriction under hypoxia by secreting H 2 O 2 to the pulmonary microenvironment." @default.
- W4241964037 created "2022-05-12" @default.
- W4241964037 creator A5005627824 @default.
- W4241964037 creator A5011877804 @default.
- W4241964037 creator A5026777101 @default.
- W4241964037 creator A5031597539 @default.
- W4241964037 creator A5044225739 @default.
- W4241964037 creator A5052500354 @default.
- W4241964037 creator A5064776877 @default.
- W4241964037 creator A5069067272 @default.
- W4241964037 creator A5084461414 @default.
- W4241964037 date "2020-12-18" @default.
- W4241964037 modified "2023-09-27" @default.
- W4241964037 title "Alveolar Epithelial Cells Involved in Pulmonary Vascular Remodeling and Constriction of Hypoxic Pulmonary Hypertension" @default.
- W4241964037 doi "https://doi.org/10.21203/rs.3.rs-129956/v1" @default.
- W4241964037 hasPublicationYear "2020" @default.
- W4241964037 type Work @default.
- W4241964037 citedByCount "0" @default.
- W4241964037 crossrefType "posted-content" @default.
- W4241964037 hasAuthorship W4241964037A5005627824 @default.
- W4241964037 hasAuthorship W4241964037A5011877804 @default.
- W4241964037 hasAuthorship W4241964037A5026777101 @default.
- W4241964037 hasAuthorship W4241964037A5031597539 @default.
- W4241964037 hasAuthorship W4241964037A5044225739 @default.
- W4241964037 hasAuthorship W4241964037A5052500354 @default.
- W4241964037 hasAuthorship W4241964037A5064776877 @default.
- W4241964037 hasAuthorship W4241964037A5069067272 @default.
- W4241964037 hasAuthorship W4241964037A5084461414 @default.
- W4241964037 hasBestOaLocation W42419640371 @default.
- W4241964037 hasConcept C126322002 @default.
- W4241964037 hasConcept C142724271 @default.
- W4241964037 hasConcept C164705383 @default.
- W4241964037 hasConcept C174940676 @default.
- W4241964037 hasConcept C178790620 @default.
- W4241964037 hasConcept C185592680 @default.
- W4241964037 hasConcept C2775838275 @default.
- W4241964037 hasConcept C2776108821 @default.
- W4241964037 hasConcept C2776151105 @default.
- W4241964037 hasConcept C2777714996 @default.
- W4241964037 hasConcept C2778979269 @default.
- W4241964037 hasConcept C2780930700 @default.
- W4241964037 hasConcept C2780940725 @default.
- W4241964037 hasConcept C29323129 @default.
- W4241964037 hasConcept C540031477 @default.
- W4241964037 hasConcept C71924100 @default.
- W4241964037 hasConcept C7836513 @default.
- W4241964037 hasConcept C98274493 @default.
- W4241964037 hasConceptScore W4241964037C126322002 @default.
- W4241964037 hasConceptScore W4241964037C142724271 @default.
- W4241964037 hasConceptScore W4241964037C164705383 @default.
- W4241964037 hasConceptScore W4241964037C174940676 @default.
- W4241964037 hasConceptScore W4241964037C178790620 @default.
- W4241964037 hasConceptScore W4241964037C185592680 @default.
- W4241964037 hasConceptScore W4241964037C2775838275 @default.
- W4241964037 hasConceptScore W4241964037C2776108821 @default.
- W4241964037 hasConceptScore W4241964037C2776151105 @default.
- W4241964037 hasConceptScore W4241964037C2777714996 @default.
- W4241964037 hasConceptScore W4241964037C2778979269 @default.
- W4241964037 hasConceptScore W4241964037C2780930700 @default.
- W4241964037 hasConceptScore W4241964037C2780940725 @default.
- W4241964037 hasConceptScore W4241964037C29323129 @default.
- W4241964037 hasConceptScore W4241964037C540031477 @default.
- W4241964037 hasConceptScore W4241964037C71924100 @default.
- W4241964037 hasConceptScore W4241964037C7836513 @default.
- W4241964037 hasConceptScore W4241964037C98274493 @default.
- W4241964037 hasLocation W42419640371 @default.
- W4241964037 hasOpenAccess W4241964037 @default.
- W4241964037 hasPrimaryLocation W42419640371 @default.
- W4241964037 hasRelatedWork W2023170905 @default.
- W4241964037 hasRelatedWork W2032306832 @default.
- W4241964037 hasRelatedWork W2113017194 @default.
- W4241964037 hasRelatedWork W2395598249 @default.
- W4241964037 hasRelatedWork W2462913190 @default.
- W4241964037 hasRelatedWork W2463110717 @default.
- W4241964037 hasRelatedWork W2793973847 @default.
- W4241964037 hasRelatedWork W3117317823 @default.
- W4241964037 hasRelatedWork W335837758 @default.
- W4241964037 hasRelatedWork W4241964037 @default.
- W4241964037 isParatext "false" @default.
- W4241964037 isRetracted "false" @default.
- W4241964037 workType "article" @default.