Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242010570> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4242010570 abstract "Abstract Background: This study was intended to investigate the genomic landscape of the immune microenvironments of brain metastases in breast cancer. Methods: Three gene expression profile datasets (GSE76714, GSE125989 and GSE43837) of breast cancer with brain metastases were downloaded from Gene Expression Omnibus (GEO) database. After differential expression analysis, the tumor immune microenvironment and immune cell infiltration were analyzed. Then immune-related genes were identified, followed by function analysis, transcription factor (TF)-miRNA-mRNA co-regulatory network analysis, and survival analysis of metastatic recurrence. Results: The present results showed that the tumor immune microenvironment in brain metastases was immunosuppressed compared with primary caner. Compared with primary cancer samples, the infiltration ratio of plasma cells in brain metastases samples was significantly higher, while the infiltration ratio of macrophages M2 cells in brain metastases samples was significantly lower. Total 42 immune-related genes were identified, such as THY1 and NEU2. CD1B, THY1 and DOCK2 were found to be implicated in the metastatic recurrence of breast cancer. Conclusions: Targeting macrophages or plasma cells may be new strategies for immunotherapy of breast cancer with brain metastases. THY1 and NEU2 may be potential therapeutic targets for breast cancer with brain metastases, and THY1, CD1B and DOCK2 may serve as potential prognostic markers for improvement of brain metastases survival." @default.
- W4242010570 created "2022-05-12" @default.
- W4242010570 creator A5013897102 @default.
- W4242010570 creator A5028836596 @default.
- W4242010570 creator A5045150831 @default.
- W4242010570 creator A5055703216 @default.
- W4242010570 creator A5087238533 @default.
- W4242010570 creator A5090956901 @default.
- W4242010570 date "2020-07-28" @default.
- W4242010570 modified "2023-09-27" @default.
- W4242010570 title "Genomic landscape of the immune microenvironments of brain metastases in breast cancer" @default.
- W4242010570 doi "https://doi.org/10.21203/rs.3.rs-25779/v2" @default.
- W4242010570 hasPublicationYear "2020" @default.
- W4242010570 type Work @default.
- W4242010570 citedByCount "0" @default.
- W4242010570 crossrefType "posted-content" @default.
- W4242010570 hasAuthorship W4242010570A5013897102 @default.
- W4242010570 hasAuthorship W4242010570A5028836596 @default.
- W4242010570 hasAuthorship W4242010570A5045150831 @default.
- W4242010570 hasAuthorship W4242010570A5055703216 @default.
- W4242010570 hasAuthorship W4242010570A5087238533 @default.
- W4242010570 hasAuthorship W4242010570A5090956901 @default.
- W4242010570 hasBestOaLocation W42420105701 @default.
- W4242010570 hasConcept C104317684 @default.
- W4242010570 hasConcept C121332964 @default.
- W4242010570 hasConcept C121608353 @default.
- W4242010570 hasConcept C126322002 @default.
- W4242010570 hasConcept C143998085 @default.
- W4242010570 hasConcept C153400128 @default.
- W4242010570 hasConcept C203014093 @default.
- W4242010570 hasConcept C2776107976 @default.
- W4242010570 hasConcept C2777701055 @default.
- W4242010570 hasConcept C2778164965 @default.
- W4242010570 hasConcept C2779013556 @default.
- W4242010570 hasConcept C2780283643 @default.
- W4242010570 hasConcept C502942594 @default.
- W4242010570 hasConcept C530470458 @default.
- W4242010570 hasConcept C55493867 @default.
- W4242010570 hasConcept C71924100 @default.
- W4242010570 hasConcept C86803240 @default.
- W4242010570 hasConcept C8891405 @default.
- W4242010570 hasConcept C97355855 @default.
- W4242010570 hasConceptScore W4242010570C104317684 @default.
- W4242010570 hasConceptScore W4242010570C121332964 @default.
- W4242010570 hasConceptScore W4242010570C121608353 @default.
- W4242010570 hasConceptScore W4242010570C126322002 @default.
- W4242010570 hasConceptScore W4242010570C143998085 @default.
- W4242010570 hasConceptScore W4242010570C153400128 @default.
- W4242010570 hasConceptScore W4242010570C203014093 @default.
- W4242010570 hasConceptScore W4242010570C2776107976 @default.
- W4242010570 hasConceptScore W4242010570C2777701055 @default.
- W4242010570 hasConceptScore W4242010570C2778164965 @default.
- W4242010570 hasConceptScore W4242010570C2779013556 @default.
- W4242010570 hasConceptScore W4242010570C2780283643 @default.
- W4242010570 hasConceptScore W4242010570C502942594 @default.
- W4242010570 hasConceptScore W4242010570C530470458 @default.
- W4242010570 hasConceptScore W4242010570C55493867 @default.
- W4242010570 hasConceptScore W4242010570C71924100 @default.
- W4242010570 hasConceptScore W4242010570C86803240 @default.
- W4242010570 hasConceptScore W4242010570C8891405 @default.
- W4242010570 hasConceptScore W4242010570C97355855 @default.
- W4242010570 hasLocation W42420105701 @default.
- W4242010570 hasLocation W42420105702 @default.
- W4242010570 hasLocation W42420105703 @default.
- W4242010570 hasOpenAccess W4242010570 @default.
- W4242010570 hasPrimaryLocation W42420105701 @default.
- W4242010570 hasRelatedWork W12835821 @default.
- W4242010570 hasRelatedWork W13888906 @default.
- W4242010570 hasRelatedWork W14333088 @default.
- W4242010570 hasRelatedWork W14868149 @default.
- W4242010570 hasRelatedWork W158596 @default.
- W4242010570 hasRelatedWork W2083469 @default.
- W4242010570 hasRelatedWork W2151330 @default.
- W4242010570 hasRelatedWork W2908475 @default.
- W4242010570 hasRelatedWork W7207526 @default.
- W4242010570 hasRelatedWork W7506178 @default.
- W4242010570 isParatext "false" @default.
- W4242010570 isRetracted "false" @default.
- W4242010570 workType "article" @default.