Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242016418> ?p ?o ?g. }
- W4242016418 endingPage "355" @default.
- W4242016418 startingPage "349" @default.
- W4242016418 abstract "UVA contributes to skin cancer by solar UV light. Photosensitizers are believed to play an important role in UVA carcinogenesis. We investigated the mechanism of DNA damage induced by photoexcited xanthone (XAN) analogues (XAN, thioxanthone [TXAN] and acridone [ACR]), exogenous photosensitizers, and the relationship between the DNA-damaging abilities and their highest occupied molecular orbital (HOMO) energies. DNA damage by these photosensitizers was examined using 32P-labeled DNA fragments obtained from the p53 tumor suppressor gene. Photoexcited XAN caused DNA cleavage specifically at 5′-G of the GG sequence in the double-stranded DNA only when the DNA fragments were treated with piperidine, suggesting that DNA cleavage is due to base modification with little or no strand breakage. With denatured single-stranded DNA, the extent of XAN-sensitized photodamage was decreased. An oxidative product of G, 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGuo), was formed by photoexcited XAN, and the 8-oxo-dGuo formation was decreased in single-stranded DNA. TXAN and ACR induced DNA photodamage as did XAN, although the order of DNA-damaging ability was XAN > TXAN > ACR. These findings suggest that photoexcited XAN analogues induce nucleobase oxidation at 5′-G of GG sequence in double-stranded DNA through electron transfer. The HOMO energies of these photosensitizers, estimated from ab initio molecular orbital (MO) calculation, decreased in the following order: XAN > TXAN > ACR. Extents of DNA damage increased exponentially with the HOMO energies of XAN analogues. This study suggests that DNA-damaging abilities of photosensitizers can be estimated from their HOMO energies." @default.
- W4242016418 created "2022-05-12" @default.
- W4242016418 creator A5019132861 @default.
- W4242016418 creator A5047559113 @default.
- W4242016418 creator A5055562110 @default.
- W4242016418 creator A5077773100 @default.
- W4242016418 date "2007-05-01" @default.
- W4242016418 modified "2023-10-17" @default.
- W4242016418 title "Base Oxidation at 5′ Site of GG Sequence in Double-stranded DNA Induced by UVA in the Presence of Xanthone Analogues: Relationship Between the DNA-damaging Abilities of Photosensitizers and Their HOMO Energies ¶" @default.
- W4242016418 cites W1558516755 @default.
- W4242016418 cites W1569192453 @default.
- W4242016418 cites W1575560358 @default.
- W4242016418 cites W1584878126 @default.
- W4242016418 cites W1590200004 @default.
- W4242016418 cites W1833739857 @default.
- W4242016418 cites W1968964329 @default.
- W4242016418 cites W1975819067 @default.
- W4242016418 cites W1977184994 @default.
- W4242016418 cites W1981000395 @default.
- W4242016418 cites W1985209282 @default.
- W4242016418 cites W1986216535 @default.
- W4242016418 cites W1988760590 @default.
- W4242016418 cites W1998430759 @default.
- W4242016418 cites W2000774559 @default.
- W4242016418 cites W2001229080 @default.
- W4242016418 cites W2001923549 @default.
- W4242016418 cites W2016633358 @default.
- W4242016418 cites W2020080089 @default.
- W4242016418 cites W2021115296 @default.
- W4242016418 cites W2025297034 @default.
- W4242016418 cites W2029009897 @default.
- W4242016418 cites W2040843368 @default.
- W4242016418 cites W2041628963 @default.
- W4242016418 cites W2048191679 @default.
- W4242016418 cites W2048607797 @default.
- W4242016418 cites W2051865375 @default.
- W4242016418 cites W2053953585 @default.
- W4242016418 cites W2055581742 @default.
- W4242016418 cites W2056077906 @default.
- W4242016418 cites W2060886270 @default.
- W4242016418 cites W2061405003 @default.
- W4242016418 cites W2063764814 @default.
- W4242016418 cites W2064344250 @default.
- W4242016418 cites W2068808996 @default.
- W4242016418 cites W2074341351 @default.
- W4242016418 cites W2079869127 @default.
- W4242016418 cites W2080941285 @default.
- W4242016418 cites W2084902130 @default.
- W4242016418 cites W2084989048 @default.
- W4242016418 cites W2085134918 @default.
- W4242016418 cites W2089722106 @default.
- W4242016418 cites W2093967217 @default.
- W4242016418 cites W2094491807 @default.
- W4242016418 cites W2095301528 @default.
- W4242016418 cites W2114556320 @default.
- W4242016418 cites W2118213383 @default.
- W4242016418 cites W2146700501 @default.
- W4242016418 cites W2154507046 @default.
- W4242016418 cites W2168136834 @default.
- W4242016418 doi "https://doi.org/10.1562/0031-8655(2003)0770349boasog2.0.co2" @default.
- W4242016418 hasPublicationYear "2007" @default.
- W4242016418 type Work @default.
- W4242016418 citedByCount "6" @default.
- W4242016418 countsByYear W42420164182015 @default.
- W4242016418 countsByYear W42420164182021 @default.
- W4242016418 crossrefType "journal-article" @default.
- W4242016418 hasAuthorship W4242016418A5019132861 @default.
- W4242016418 hasAuthorship W4242016418A5047559113 @default.
- W4242016418 hasAuthorship W4242016418A5055562110 @default.
- W4242016418 hasAuthorship W4242016418A5077773100 @default.
- W4242016418 hasConcept C143425029 @default.
- W4242016418 hasConcept C185581394 @default.
- W4242016418 hasConcept C185592680 @default.
- W4242016418 hasConcept C552990157 @default.
- W4242016418 hasConcept C55493867 @default.
- W4242016418 hasConcept C61234307 @default.
- W4242016418 hasConcept C71240020 @default.
- W4242016418 hasConcept C75473681 @default.
- W4242016418 hasConceptScore W4242016418C143425029 @default.
- W4242016418 hasConceptScore W4242016418C185581394 @default.
- W4242016418 hasConceptScore W4242016418C185592680 @default.
- W4242016418 hasConceptScore W4242016418C552990157 @default.
- W4242016418 hasConceptScore W4242016418C55493867 @default.
- W4242016418 hasConceptScore W4242016418C61234307 @default.
- W4242016418 hasConceptScore W4242016418C71240020 @default.
- W4242016418 hasConceptScore W4242016418C75473681 @default.
- W4242016418 hasIssue "4" @default.
- W4242016418 hasLocation W42420164181 @default.
- W4242016418 hasOpenAccess W4242016418 @default.
- W4242016418 hasPrimaryLocation W42420164181 @default.
- W4242016418 hasRelatedWork W1984441743 @default.
- W4242016418 hasRelatedWork W2033358700 @default.
- W4242016418 hasRelatedWork W2055602243 @default.
- W4242016418 hasRelatedWork W2096508529 @default.
- W4242016418 hasRelatedWork W2152093192 @default.
- W4242016418 hasRelatedWork W2168044784 @default.
- W4242016418 hasRelatedWork W2804057239 @default.
- W4242016418 hasRelatedWork W2904141667 @default.