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- W4242049077 abstract "Various drugs with or without sulfur groups have been demonstrated to exert antioxidant properties in vivo. In this latter group immunomodulating agents such as the polyribonucleotide Poly(I)-Poly(C) have been shown to protect rats against hyperoxic pulmonary damage. However, the effects of these agents on the protection of immune cells against oxidative injury have not been described. Our work shows that the immunomodulating agent Poly(A)-Poly(U) administered in vivo to mice protected their lymphoid cells against immune oxidative injury by increasing their glutathione content. This antioxidant effect could be related to the Poly(A)-Poly(U) capacity to induce the release of thiol compounds from macrophages. The antioxidant effects of such a non toxic immunomodulating agent could be of interest in protecting lymphoid cells in pathological situations involving oxidative injury." @default.
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- W4242049077 date "1994-01-01" @default.
- W4242049077 modified "2023-09-27" @default.
- W4242049077 title "Protective effect of Poly(A)-Poly(U) against immune oxidative injury. Role of thiols released by activated macrophages" @default.
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- W4242049077 doi "https://doi.org/10.1007/978-3-0348-7424-3_18" @default.
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