Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242056598> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4242056598 abstract "The term 'scleroderma' describes a group of conditions in which the development of thickened, fibrotic skin is a cardinal feature. This includes localized forms of scleroderma (e.g. morphoea) and also systemic forms of the disease that are more correctly termed systemic sclerosis. Systemic sclerosis (SSc) is a multiorgan, autoimmune disease that has a high clinical burden and mortality, due to affecting the skin as well as internal organs. As with other related diseases there is a female predominance and marked clinical diversity. The pathogenesis of SSc is not fully elucidated; it includes endothelial cell injury fibroblast activation and autoimmunity that lead to skin and internal organ manifestations. The majority of cases exhibit characteristic serum autoantibodies. Some of these antibodies are scleroderma-specific reactivities including anti-centromere (ACA), anti-topoisomerase-1 (ATA or Scl 70) or anti-RNA polymerase III antibodies. These anti-nuclear antibody (ANA) patterns are generally mutually exclusive and serve as useful clinical markers of disease subgroups. Additional subsetting of scleroderma cases, based on the extent of skin sclerosis, permits classification into limited and diffuse subsets. Because of the heterogeneity of the disease patients may suffer from different organ manifestations, such as lung fibrosis, hypertensive renal crisis, severe cardiac disease, gastrointestinal involvement, and pulmonary arterial hypertension. Although outcomes have improved recently, systemic sclerosis still has the highest case-specific mortality of any of the autoimmune rheumatic diseases and requires careful and systematic investigation, management and follow-up. Treatment includes symptomatic strategies with attention to each involved organ system; it is still an area where therapeutic progress and better understanding of pathogenesis is increasingly anticipated." @default.
- W4242056598 created "2022-05-12" @default.
- W4242056598 creator A5008098676 @default.
- W4242056598 creator A5069180045 @default.
- W4242056598 date "2013-10-01" @default.
- W4242056598 modified "2023-09-25" @default.
- W4242056598 title "Systemic sclerosis" @default.
- W4242056598 doi "https://doi.org/10.1093/med/9780199642489.003.0121" @default.
- W4242056598 hasPublicationYear "2013" @default.
- W4242056598 type Work @default.
- W4242056598 citedByCount "3" @default.
- W4242056598 countsByYear W42420565982017 @default.
- W4242056598 countsByYear W42420565982018 @default.
- W4242056598 crossrefType "book" @default.
- W4242056598 hasAuthorship W4242056598A5008098676 @default.
- W4242056598 hasAuthorship W4242056598A5069180045 @default.
- W4242056598 hasConcept C126322002 @default.
- W4242056598 hasConcept C142724271 @default.
- W4242056598 hasConcept C159654299 @default.
- W4242056598 hasConcept C163764329 @default.
- W4242056598 hasConcept C180032290 @default.
- W4242056598 hasConcept C203014093 @default.
- W4242056598 hasConcept C2777543607 @default.
- W4242056598 hasConcept C2777714996 @default.
- W4242056598 hasConcept C2778674544 @default.
- W4242056598 hasConcept C2779075594 @default.
- W4242056598 hasConcept C2779134260 @default.
- W4242056598 hasConcept C2779967694 @default.
- W4242056598 hasConcept C2780559512 @default.
- W4242056598 hasConcept C2780930700 @default.
- W4242056598 hasConcept C2781244666 @default.
- W4242056598 hasConcept C71924100 @default.
- W4242056598 hasConceptScore W4242056598C126322002 @default.
- W4242056598 hasConceptScore W4242056598C142724271 @default.
- W4242056598 hasConceptScore W4242056598C159654299 @default.
- W4242056598 hasConceptScore W4242056598C163764329 @default.
- W4242056598 hasConceptScore W4242056598C180032290 @default.
- W4242056598 hasConceptScore W4242056598C203014093 @default.
- W4242056598 hasConceptScore W4242056598C2777543607 @default.
- W4242056598 hasConceptScore W4242056598C2777714996 @default.
- W4242056598 hasConceptScore W4242056598C2778674544 @default.
- W4242056598 hasConceptScore W4242056598C2779075594 @default.
- W4242056598 hasConceptScore W4242056598C2779134260 @default.
- W4242056598 hasConceptScore W4242056598C2779967694 @default.
- W4242056598 hasConceptScore W4242056598C2780559512 @default.
- W4242056598 hasConceptScore W4242056598C2780930700 @default.
- W4242056598 hasConceptScore W4242056598C2781244666 @default.
- W4242056598 hasConceptScore W4242056598C71924100 @default.
- W4242056598 hasLocation W42420565981 @default.
- W4242056598 hasOpenAccess W4242056598 @default.
- W4242056598 hasPrimaryLocation W42420565981 @default.
- W4242056598 hasRelatedWork W10945603 @default.
- W4242056598 hasRelatedWork W1574259 @default.
- W4242056598 hasRelatedWork W1813641 @default.
- W4242056598 hasRelatedWork W18825832 @default.
- W4242056598 hasRelatedWork W20154870 @default.
- W4242056598 hasRelatedWork W2097657 @default.
- W4242056598 hasRelatedWork W21319944 @default.
- W4242056598 hasRelatedWork W2233737 @default.
- W4242056598 hasRelatedWork W9506558 @default.
- W4242056598 hasRelatedWork W992371 @default.
- W4242056598 isParatext "false" @default.
- W4242056598 isRetracted "false" @default.
- W4242056598 workType "book" @default.