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- W4242075615 abstract "Results from previous studies from our laboratory have shown that T cells obtained from the spleens of C57BL/6 mice that consumed ethanol chronically have increased expression of activation markers and increased second signal–independent production of interferon-gamma (IFN-γ). We now report that in vitro–activated CD11b+ splenocytes obtained from C57BL/6 and BALB/c mice that consumed ethanol chronically express increased levels of the T cell co-stimulatory molecules CD80 and CD86. CD11b+ splenocytes encompass at least two populations: the CD11b+Gr.1− population, which is primarily monocytes–macrophages, and a smaller CD11b+Gr.1+ population, which is in the myelocytic–monocytic cell series and contains precursors of both macrophages and neutrophils. Evaluation of cultures of purified CD11b+ cells, obtained from mice that consumed ethanol chronically, incubated overnight, showed increased up-regulation of CD80 and CD86 expression on Gr.1− mouse splenic macrophages. Results of functional studies of purified CD11b+ cells have demonstrated that CD11b+ cells obtained from C57BL/6 mice that were exposed to ethanol chronically secrete higher levels, in comparison with the levels secreted by CD11b+ cells obtained from control animals, of nitric oxide and several proinflammatory cytokines after stimulation by the oligodeoxynucleotide (ODN) CpG 1826. These findings indicate that CD11b+ splenocytes are in some way sensitized to activating stimuli by chronic ethanol exposure in vivo. Such cells may contribute to systemic immunodysregulation, including T-cell activation, by providing abnormal second signals to T cells, or through excessive release of cytokines, such as interleukin (IL)-6 or IL-12." @default.
- W4242075615 created "2022-05-12" @default.
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- W4242075615 date "2004-02-01" @default.
- W4242075615 modified "2023-09-27" @default.
- W4242075615 title "Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages*1" @default.
- W4242075615 doi "https://doi.org/10.1016/s0741-8329(04)00011-4" @default.
- W4242075615 hasPublicationYear "2004" @default.
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