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• W4242087497 abstract "We thank Rebolleda et al for their interest in our study, who proposed that the morphologic changes of the retinal pigment epithelium (RPE) seen after an acute increase in intraocular pressure (IOP) may be related to a potential increase in IOP associated expansion of Bruch's membrane opening.1Wang Y.X. Jiang R. Wang N.L. et al.Acute peripapillary retinal pigment epithelium changes associated with acute intraocular pressure elevation.Ophthalmology. 2015; 122: 2022-2028Abstract Full Text Full Text PDF PubMed Scopus (34) Google Scholar As reported in another recent article, the increase in IOP observed in the dark room prone provocative test was associated with a widening and deepening of the optic cup, a decrease in neuroretinal rim width, and a thinning of the lamina cribrosa.2Jiang R. Xu L. Liu X. et al.Optic nerve head changes after short-term intraocular pressure elevation in acute primary angle-closure suspects.Ophthalmology. 2015; 122: 730-737Abstract Full Text Full Text PDF PubMed Scopus (32) Google Scholar The diameter of Bruch's membrane opening, however, did not differ between the measurements taken at baseline and the measurements performed 2 hours later at a high IOP (1530±139 vs 1531±136 μm; P = 0.873). It suggests that the changes in the morphology of the RPE observed at the end of Bruch's membrane after the increase in IOP may not have been caused by a widening of Bruch's membrane opening. Also, if the Bruch's membrane opening had widened during the period of increased high IOP, one might have expected a shifting of the RPE toward the end of Bruch's membrane, or at least a constant distance between the end of the RPE and the end of Bruch's membrane. However, we observed that the distance between the RPE end and the end of Bruch's membrane enlarged during the phase of increased IOP. Re: Wang et al.: Acute peripapillary retinal pigment epithelium changes associated with acute intraocular pressure elevation (Ophthalmology 2015,122:2022-8)OphthalmologyVol. 123Issue 5PreviewWe read with great interest the study by Wang et al,1 in which folding and/or centrifugal sliding of the peripapillary retinal pigment epithelium (RPE) were observed in 95% of eyes suffering an acute increase in intraocular pressure (of >15 mmHg) after a dark room prone provocative test. These morphologic changes reversed after intraocular pressure reduction and were not observed in control eyes. Full-Text PDF" @default.
• W4242087497 created "2022-05-12" @default.
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• W4242087497 date "2016-05-01" @default.
• W4242087497 modified "2023-09-26" @default.
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• W4242087497 doi "https://doi.org/10.1016/j.ophtha.2015.11.025" @default.
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