Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242090410> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4242090410 endingPage "4485" @default.
- W4242090410 startingPage "4485" @default.
- W4242090410 abstract "Abstract Abstract 4485 Myeloablative conditioning prior to bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T cell immune deficiency, and susceptibility to opportunistic infections. Conditioning regimen-induced TEC damage directly contributes to slow thymopoietic recovery following BMT. Keratinocyte growth factor (KGF) is a TEC mitogen that stimulates proliferation and, when given prior to conditioning, reduces TEC injury. Some TEC subsets are refractory to KGF and functional T-cell responses are not fully restored in KGF-treated BMT recipients. Therefore, we investigated whether the addition of a pharmacological inhibitor, PFT-β to transiently inhibit p53 during radiotherapy could spare TEC from radiation-induced damage in congenic and allogeneic BMT. The combined pre-BMT administration of KGF plus PFT-β additively restored numbers of cortical and medullary TEC and improved thymic function post-BMT, resulting in higher numbers of donor-derived, naïve peripheral CD4+ and CD8+ T-cells. Improved T-cell reconstitution correlated with enhanced recovery of fibroblastic reticular cells in the lymph node stromal compartment, and a superior immune response against L. monocytogenes infection. Thus, transient p53-inhibition combined with KGF represents a novel and potentially translatable approach to promote rapid and durable thymic and peripheral T-cell recovery following BMT. Disclosures: No relevant conflicts of interest to declare." @default.
- W4242090410 created "2022-05-12" @default.
- W4242090410 creator A5032181613 @default.
- W4242090410 creator A5058268746 @default.
- W4242090410 creator A5062830968 @default.
- W4242090410 creator A5063708452 @default.
- W4242090410 creator A5079128426 @default.
- W4242090410 creator A5084319746 @default.
- W4242090410 creator A5089383405 @default.
- W4242090410 creator A5090555265 @default.
- W4242090410 date "2009-11-20" @default.
- W4242090410 modified "2023-10-17" @default.
- W4242090410 title "Short-Term Inhibition of p53 Combined with Keratinocyte Growth Factor Improves Thymic Epithelial Cell Recovery and Enhances T-Cell Reconstitution After Murine Bone Marrow Transplantation." @default.
- W4242090410 doi "https://doi.org/10.1182/blood.v114.22.4485.4485" @default.
- W4242090410 hasPublicationYear "2009" @default.
- W4242090410 type Work @default.
- W4242090410 citedByCount "0" @default.
- W4242090410 crossrefType "journal-article" @default.
- W4242090410 hasAuthorship W4242090410A5032181613 @default.
- W4242090410 hasAuthorship W4242090410A5058268746 @default.
- W4242090410 hasAuthorship W4242090410A5062830968 @default.
- W4242090410 hasAuthorship W4242090410A5063708452 @default.
- W4242090410 hasAuthorship W4242090410A5079128426 @default.
- W4242090410 hasAuthorship W4242090410A5084319746 @default.
- W4242090410 hasAuthorship W4242090410A5089383405 @default.
- W4242090410 hasAuthorship W4242090410A5090555265 @default.
- W4242090410 hasConcept C116403925 @default.
- W4242090410 hasConcept C121332964 @default.
- W4242090410 hasConcept C126322002 @default.
- W4242090410 hasConcept C1276947 @default.
- W4242090410 hasConcept C167672396 @default.
- W4242090410 hasConcept C16930146 @default.
- W4242090410 hasConcept C170493617 @default.
- W4242090410 hasConcept C176379880 @default.
- W4242090410 hasConcept C203014093 @default.
- W4242090410 hasConcept C2775960820 @default.
- W4242090410 hasConcept C2776090121 @default.
- W4242090410 hasConcept C2778615670 @default.
- W4242090410 hasConcept C2780007613 @default.
- W4242090410 hasConcept C2911091166 @default.
- W4242090410 hasConcept C502942594 @default.
- W4242090410 hasConcept C54355233 @default.
- W4242090410 hasConcept C62112901 @default.
- W4242090410 hasConcept C71924100 @default.
- W4242090410 hasConcept C86803240 @default.
- W4242090410 hasConcept C8891405 @default.
- W4242090410 hasConceptScore W4242090410C116403925 @default.
- W4242090410 hasConceptScore W4242090410C121332964 @default.
- W4242090410 hasConceptScore W4242090410C126322002 @default.
- W4242090410 hasConceptScore W4242090410C1276947 @default.
- W4242090410 hasConceptScore W4242090410C167672396 @default.
- W4242090410 hasConceptScore W4242090410C16930146 @default.
- W4242090410 hasConceptScore W4242090410C170493617 @default.
- W4242090410 hasConceptScore W4242090410C176379880 @default.
- W4242090410 hasConceptScore W4242090410C203014093 @default.
- W4242090410 hasConceptScore W4242090410C2775960820 @default.
- W4242090410 hasConceptScore W4242090410C2776090121 @default.
- W4242090410 hasConceptScore W4242090410C2778615670 @default.
- W4242090410 hasConceptScore W4242090410C2780007613 @default.
- W4242090410 hasConceptScore W4242090410C2911091166 @default.
- W4242090410 hasConceptScore W4242090410C502942594 @default.
- W4242090410 hasConceptScore W4242090410C54355233 @default.
- W4242090410 hasConceptScore W4242090410C62112901 @default.
- W4242090410 hasConceptScore W4242090410C71924100 @default.
- W4242090410 hasConceptScore W4242090410C86803240 @default.
- W4242090410 hasConceptScore W4242090410C8891405 @default.
- W4242090410 hasIssue "22" @default.
- W4242090410 hasLocation W42420904101 @default.
- W4242090410 hasOpenAccess W4242090410 @default.
- W4242090410 hasPrimaryLocation W42420904101 @default.
- W4242090410 hasRelatedWork W1395124 @default.
- W4242090410 hasRelatedWork W1612011 @default.
- W4242090410 hasRelatedWork W2035298 @default.
- W4242090410 hasRelatedWork W2290790 @default.
- W4242090410 hasRelatedWork W3457115 @default.
- W4242090410 hasRelatedWork W4732904 @default.
- W4242090410 hasRelatedWork W6386332 @default.
- W4242090410 hasRelatedWork W7520092 @default.
- W4242090410 hasRelatedWork W860291 @default.
- W4242090410 hasRelatedWork W8758018 @default.
- W4242090410 hasVolume "114" @default.
- W4242090410 isParatext "false" @default.
- W4242090410 isRetracted "false" @default.
- W4242090410 workType "article" @default.