FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242091960> ?p ?o ?g. }

• W4242091960 endingPage "177" @default.
• W4242091960 startingPage "173" @default.
• W4242091960 abstract "Non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) have been proposed to have a mutual developmental mechanism, but their association has not been fully understood. We aimed to examine the association of the mutational landscape of NSCLC with co-morbid COPD.A total of 197 surgical specimens of early stage NSCLC were retrospectively collected from two independent sources, namely, the Japan Molecular Epidemiology for Lung Cancer Study and the Osaka City University Hospital cohort from 2010 to 2013. COPD and its severity were defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and grading system. For molecular profiling of NSCLC patients with COPD, the extracted DNAs were deep-sequenced using next generation sequence technologies for somatic mutations in a maximum 72 cancer-associated genes. Logistic regression analysis was performed to evaluate the impact of COPD on the somatic mutations.The COPD group (n = 77), including 56 GOLD 1 and 21 GOLD 2 or 3 patients, had 58 squamous cell lung carcinoma (SCC) cases and 19 adenocarcinoma cases. The non-COPD group (n = 120) had 53 SCC cases, 64 adenocarcinoma cases, and three cases with other histology. The frequency of PIK3CA mutation was significantly higher in the COPD group than in the non-COPD group (10.4% vs. 1.7%, p = 0.015). Meanwhile, NFE2L2 mutation was observed only in SCC cases, with no difference in the frequency between the two groups (17.2% vs. 17.0%). In the multivariate logistic regression model with consideration for COPD status, age, smoking dose, pathological stage, and histology, significantly more PIK3CA mutation was observed in the presence of COPD (odds ratio = 5.31, 95% CI: 1.03–27.29, p = 0.046).PIK3CA mutation is a distinctive genetic feature of NSCLC with COPD, regardless of age, smoking dose, pathological stage, and histology." @default.
• W4242091960 created "2022-05-12" @default.
• W4242091960 creator A5012346270 @default.
• W4242091960 creator A5044799138 @default.
• W4242091960 date "2011-07-01" @default.
• W4242091960 modified "2023-09-25" @default.
• W4242091960 title "Epidemiology of Lung Cancer" @default.
• W4242091960 cites W1484998269 @default.
• W4242091960 cites W1984852348 @default.
• W4242091960 cites W1984940554 @default.
• W4242091960 cites W1989687673 @default.
• W4242091960 cites W1994553264 @default.
• W4242091960 cites W1996475083 @default.
• W4242091960 cites W2011676048 @default.
• W4242091960 cites W2029446677 @default.
• W4242091960 cites W2037641049 @default.
• W4242091960 cites W2037906880 @default.
• W4242091960 cites W2048538776 @default.
• W4242091960 cites W2053398948 @default.
• W4242091960 cites W2067485283 @default.
• W4242091960 cites W2089300758 @default.
• W4242091960 cites W2095081508 @default.
• W4242091960 cites W2102232287 @default.
• W4242091960 cites W2102250046 @default.
• W4242091960 cites W2105152630 @default.
• W4242091960 cites W2122360825 @default.
• W4242091960 cites W2125195105 @default.
• W4242091960 cites W2125969921 @default.
• W4242091960 cites W2138960985 @default.
• W4242091960 cites W2139236349 @default.
• W4242091960 cites W2142850084 @default.
• W4242091960 cites W2149882871 @default.
• W4242091960 cites W2165689775 @default.
• W4242091960 cites W2252688746 @default.
• W4242091960 cites W2313715674 @default.
• W4242091960 cites W2318178900 @default.
• W4242091960 cites W2406501398 @default.
• W4242091960 cites W4292230194 @default.
• W4242091960 doi "https://doi.org/10.1053/j.ro.2011.02.002" @default.
• W4242091960 hasPublicationYear "2011" @default.
• W4242091960 type Work @default.
• W4242091960 citedByCount "30" @default.
• W4242091960 countsByYear W42420919602012 @default.
• W4242091960 countsByYear W42420919602013 @default.
• W4242091960 countsByYear W42420919602014 @default.
• W4242091960 countsByYear W42420919602015 @default.
• W4242091960 countsByYear W42420919602016 @default.
• W4242091960 countsByYear W42420919602017 @default.
• W4242091960 countsByYear W42420919602018 @default.
• W4242091960 countsByYear W42420919602019 @default.
• W4242091960 countsByYear W42420919602020 @default.
• W4242091960 countsByYear W42420919602021 @default.
• W4242091960 countsByYear W42420919602022 @default.
• W4242091960 crossrefType "journal-article" @default.
• W4242091960 hasAuthorship W4242091960A5012346270 @default.
• W4242091960 hasAuthorship W4242091960A5044799138 @default.
• W4242091960 hasConcept C107130276 @default.
• W4242091960 hasConcept C121608353 @default.
• W4242091960 hasConcept C126322002 @default.
• W4242091960 hasConcept C142724271 @default.
• W4242091960 hasConcept C143998085 @default.
• W4242091960 hasConcept C151956035 @default.
• W4242091960 hasConcept C2776256026 @default.
• W4242091960 hasConcept C2776780178 @default.
• W4242091960 hasConcept C2777104659 @default.
• W4242091960 hasConcept C2781182431 @default.
• W4242091960 hasConcept C71924100 @default.
• W4242091960 hasConcept C72563966 @default.
• W4242091960 hasConceptScore W4242091960C107130276 @default.
• W4242091960 hasConceptScore W4242091960C121608353 @default.
• W4242091960 hasConceptScore W4242091960C126322002 @default.
• W4242091960 hasConceptScore W4242091960C142724271 @default.
• W4242091960 hasConceptScore W4242091960C143998085 @default.
• W4242091960 hasConceptScore W4242091960C151956035 @default.
• W4242091960 hasConceptScore W4242091960C2776256026 @default.
• W4242091960 hasConceptScore W4242091960C2776780178 @default.
• W4242091960 hasConceptScore W4242091960C2777104659 @default.
• W4242091960 hasConceptScore W4242091960C2781182431 @default.
• W4242091960 hasConceptScore W4242091960C71924100 @default.
• W4242091960 hasConceptScore W4242091960C72563966 @default.
• W4242091960 hasIssue "3" @default.
• W4242091960 hasLocation W42420919601 @default.
• W4242091960 hasOpenAccess W4242091960 @default.
• W4242091960 hasPrimaryLocation W42420919601 @default.
• W4242091960 hasRelatedWork W1962632992 @default.
• W4242091960 hasRelatedWork W2169237347 @default.
• W4242091960 hasRelatedWork W2365807238 @default.
• W4242091960 hasRelatedWork W2375392632 @default.
• W4242091960 hasRelatedWork W2403361534 @default.
• W4242091960 hasRelatedWork W2413421841 @default.
• W4242091960 hasRelatedWork W2800008262 @default.
• W4242091960 hasRelatedWork W3137556580 @default.
• W4242091960 hasRelatedWork W3207889638 @default.
• W4242091960 hasRelatedWork W4200188553 @default.
• W4242091960 hasVolume "46" @default.
• W4242091960 isParatext "false" @default.
• W4242091960 isRetracted "false" @default.
• W4242091960 workType "article" @default.