Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242096742> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4242096742 abstract "<p><b>Rationale: </b>Head space gas chromatography (HS-GC) has become a widely used analytical technique for residual solvents determination in drug substances and drug products. During our method development of residual solvents by HS-GC for certain drug substances, four unknown peaks were observed when dimethyl sulfoxide (DMSO) was employed as sample diluent.</p><p><b>Methods:</b> Use of other sample diluents replacing DMSO did not show these unknown peaks in the HS-GC analysis. HS-GC-MS was then utilized to investigate these peaks. As part of the investigation, DMSO-<i>d<sub>6</sub></i> was used to trace the origins of these unknown peaks to DMSO. A stress study of methanethiol and formic acid was carried out to provide further evidence that <i>S</i>-methyl methanethioate was one of the unknown peaks observed during the original HS-GC analysis.<b></b></p><p><b>Results:</b> The four unknown peaks have been identified as methanethiol, dimethylsulfide, <i>S</i>-methyl methanethioate, and dimethyldisulfide, respectively, and it has been demonstrated that the four peaks are clearly related to DMSO through the use of its deuterated counterpart. Plausible formation mechanisms of these species are proposed.</p><p><b>Conclusions:</b> The occurrence of the peaks is due to minor degradation of DMSO, facilitated by certain drug substances as analytes of the analysis. These peaks are artifacts, rather than genuine impurities of the drug substances. These artifact peaks could widely occur in HS-GC analysis, when DMSO is used as sample diluent.</p>" @default.
- W4242096742 created "2022-05-12" @default.
- W4242096742 creator A5032915476 @default.
- W4242096742 creator A5039837606 @default.
- W4242096742 creator A5042241049 @default.
- W4242096742 creator A5045712324 @default.
- W4242096742 creator A5049459192 @default.
- W4242096742 creator A5052024256 @default.
- W4242096742 creator A5053403248 @default.
- W4242096742 creator A5071894027 @default.
- W4242096742 creator A5083265240 @default.
- W4242096742 date "2021-06-14" @default.
- W4242096742 modified "2023-09-24" @default.
- W4242096742 title "Artifact Peaks Due to Minor Decomposition of Sample Diluent DMSO in Head Space-GC Analysis: Mass Spectrometric Investigation Using Deuterated DMSO and Quadrupole Time-of-Flight Mass Detection" @default.
- W4242096742 doi "https://doi.org/10.26434/chemrxiv.14776473" @default.
- W4242096742 hasPublicationYear "2021" @default.
- W4242096742 type Work @default.
- W4242096742 citedByCount "0" @default.
- W4242096742 crossrefType "posted-content" @default.
- W4242096742 hasAuthorship W4242096742A5032915476 @default.
- W4242096742 hasAuthorship W4242096742A5039837606 @default.
- W4242096742 hasAuthorship W4242096742A5042241049 @default.
- W4242096742 hasAuthorship W4242096742A5045712324 @default.
- W4242096742 hasAuthorship W4242096742A5049459192 @default.
- W4242096742 hasAuthorship W4242096742A5052024256 @default.
- W4242096742 hasAuthorship W4242096742A5053403248 @default.
- W4242096742 hasAuthorship W4242096742A5071894027 @default.
- W4242096742 hasAuthorship W4242096742A5083265240 @default.
- W4242096742 hasBestOaLocation W42420967421 @default.
- W4242096742 hasConcept C113196181 @default.
- W4242096742 hasConcept C121332964 @default.
- W4242096742 hasConcept C123460561 @default.
- W4242096742 hasConcept C124681953 @default.
- W4242096742 hasConcept C13965031 @default.
- W4242096742 hasConcept C175804951 @default.
- W4242096742 hasConcept C178790620 @default.
- W4242096742 hasConcept C185592680 @default.
- W4242096742 hasConcept C2776353806 @default.
- W4242096742 hasConcept C2777379063 @default.
- W4242096742 hasConcept C43617362 @default.
- W4242096742 hasConcept C518881349 @default.
- W4242096742 hasConcept C58364064 @default.
- W4242096742 hasConcept C62520636 @default.
- W4242096742 hasConceptScore W4242096742C113196181 @default.
- W4242096742 hasConceptScore W4242096742C121332964 @default.
- W4242096742 hasConceptScore W4242096742C123460561 @default.
- W4242096742 hasConceptScore W4242096742C124681953 @default.
- W4242096742 hasConceptScore W4242096742C13965031 @default.
- W4242096742 hasConceptScore W4242096742C175804951 @default.
- W4242096742 hasConceptScore W4242096742C178790620 @default.
- W4242096742 hasConceptScore W4242096742C185592680 @default.
- W4242096742 hasConceptScore W4242096742C2776353806 @default.
- W4242096742 hasConceptScore W4242096742C2777379063 @default.
- W4242096742 hasConceptScore W4242096742C43617362 @default.
- W4242096742 hasConceptScore W4242096742C518881349 @default.
- W4242096742 hasConceptScore W4242096742C58364064 @default.
- W4242096742 hasConceptScore W4242096742C62520636 @default.
- W4242096742 hasLocation W42420967421 @default.
- W4242096742 hasOpenAccess W4242096742 @default.
- W4242096742 hasPrimaryLocation W42420967421 @default.
- W4242096742 hasRelatedWork W1855387561 @default.
- W4242096742 hasRelatedWork W1964530955 @default.
- W4242096742 hasRelatedWork W1982563862 @default.
- W4242096742 hasRelatedWork W2025615380 @default.
- W4242096742 hasRelatedWork W2057738984 @default.
- W4242096742 hasRelatedWork W2061953482 @default.
- W4242096742 hasRelatedWork W2949865739 @default.
- W4242096742 hasRelatedWork W2952356473 @default.
- W4242096742 hasRelatedWork W4256273704 @default.
- W4242096742 hasRelatedWork W2495094508 @default.
- W4242096742 isParatext "false" @default.
- W4242096742 isRetracted "false" @default.
- W4242096742 workType "article" @default.