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- W4242135142 abstract "Tamoxifen citrate is a nonsteroidal antiestrogen. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. It is approved for treatment of metastatic breast cancer in men and women. Tamoxifen in women increases the incidence of superficial phlebitis but most randomized controlled trials did not show an increased incidence of deep venous thrombosis (DVT) or pulmonary embolism (PE). Among women taking adjuvant tamoxifen for breast cancer, those who had a thrombotic event were nearly 5 times more likely to carry a factor V Leiden mutation than those who did not have a thromboembolism. Retrospective evaluation of small numbers of men who received tamoxifen for breast cancer showed higher rates of venous thromboembolism (VTE) and higher rates of DVT than in women who participated in randomized controlled trials." @default.
- W4242135142 created "2022-05-12" @default.
- W4242135142 date "2016-04-08" @default.
- W4242135142 modified "2023-10-17" @default.
- W4242135142 title "Tamoxifen" @default.
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- W4242135142 doi "https://doi.org/10.1002/9781119039112.ch39" @default.
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