FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242193754> ?p ?o ?g. }

• W4242193754 endingPage "1096" @default.
• W4242193754 startingPage "1091" @default.
• W4242193754 abstract "Familial essential thrombocythemia (ET) is inherited in an autosomal-dominant manner. This finding implies that familial ET may arise as a consequence of a mutation(s) that activates platelet production. In 1994, the thrombopoietin (TPO) gene was isolated and cloned. The TPO-TPO receptor, encoded for by thec-mpl gene, are essential regulators of thrombopoiesis. Alterations of TPO or c-Mpl thus may constitute a pathogenic event leading to familial ET. In a case of familial ET presented in our institute, serum TPO levels were significantly elevated in affected members of the family as compared with nonaffected members. Moreover, we identified a one-base deletion in the 5′-untranslated region of theTPO gene in affected but not in nonaffected family members. In vitro experiments showed that the identified mutation increased TPO production. Based on our findings, we propose that this region of theTPO gene may play a crucial role in regulating TPO expression. Our results strongly suggest that the identified mutation leads to familial ET. © 1998 by The American Society of Hematology." @default.
• W4242193754 created "2022-05-12" @default.
• W4242193754 creator A5019054546 @default.
• W4242193754 creator A5027412987 @default.
• W4242193754 creator A5035118858 @default.
• W4242193754 creator A5042868468 @default.
• W4242193754 creator A5059256758 @default.
• W4242193754 creator A5064182775 @default.
• W4242193754 creator A5084948921 @default.
• W4242193754 creator A5085155039 @default.
• W4242193754 date "1998-08-15" @default.
• W4242193754 modified "2023-09-29" @default.
• W4242193754 title "Familial Essential Thrombocythemia Associated With One-Base Deletion in the 5′-Untranslated Region of theThrombopoietin Gene" @default.
• W4242193754 cites W1484213444 @default.
• W4242193754 cites W1509246083 @default.
• W4242193754 cites W1544350757 @default.
• W4242193754 cites W1586781757 @default.
• W4242193754 cites W193519295 @default.
• W4242193754 cites W1965375035 @default.
• W4242193754 cites W1983612778 @default.
• W4242193754 cites W1995449347 @default.
• W4242193754 cites W1997632886 @default.
• W4242193754 cites W1998365820 @default.
• W4242193754 cites W2011722739 @default.
• W4242193754 cites W2027201363 @default.
• W4242193754 cites W2038818733 @default.
• W4242193754 cites W2058575876 @default.
• W4242193754 cites W2086567353 @default.
• W4242193754 cites W2093758335 @default.
• W4242193754 cites W2095938007 @default.
• W4242193754 cites W2120056767 @default.
• W4242193754 cites W2140818834 @default.
• W4242193754 cites W2143531841 @default.
• W4242193754 cites W2145139769 @default.
• W4242193754 cites W2145376670 @default.
• W4242193754 cites W2153697948 @default.
• W4242193754 cites W2230842386 @default.
• W4242193754 cites W2260183312 @default.
• W4242193754 cites W2313156944 @default.
• W4242193754 cites W2417688184 @default.
• W4242193754 cites W2419527806 @default.
• W4242193754 cites W4239174978 @default.
• W4242193754 cites W4250877630 @default.
• W4242193754 doi "https://doi.org/10.1182/blood.v92.4.1091.416a36_1091_1096" @default.
• W4242193754 hasPublicationYear "1998" @default.
• W4242193754 type Work @default.
• W4242193754 citedByCount "3" @default.
• W4242193754 countsByYear W42421937542021 @default.
• W4242193754 crossrefType "journal-article" @default.
• W4242193754 hasAuthorship W4242193754A5019054546 @default.
• W4242193754 hasAuthorship W4242193754A5027412987 @default.
• W4242193754 hasAuthorship W4242193754A5035118858 @default.
• W4242193754 hasAuthorship W4242193754A5042868468 @default.
• W4242193754 hasAuthorship W4242193754A5059256758 @default.
• W4242193754 hasAuthorship W4242193754A5064182775 @default.
• W4242193754 hasAuthorship W4242193754A5084948921 @default.
• W4242193754 hasAuthorship W4242193754A5085155039 @default.
• W4242193754 hasConcept C104317684 @default.
• W4242193754 hasConcept C105580179 @default.
• W4242193754 hasConcept C109159458 @default.
• W4242193754 hasConcept C153911025 @default.
• W4242193754 hasConcept C203014093 @default.
• W4242193754 hasConcept C2776958478 @default.
• W4242193754 hasConcept C2777863708 @default.
• W4242193754 hasConcept C2778713057 @default.
• W4242193754 hasConcept C2778837598 @default.
• W4242193754 hasConcept C2779705218 @default.
• W4242193754 hasConcept C2781057849 @default.
• W4242193754 hasConcept C28328180 @default.
• W4242193754 hasConcept C501734568 @default.
• W4242193754 hasConcept C502942594 @default.
• W4242193754 hasConcept C54355233 @default.
• W4242193754 hasConcept C86803240 @default.
• W4242193754 hasConcept C89604277 @default.
• W4242193754 hasConceptScore W4242193754C104317684 @default.
• W4242193754 hasConceptScore W4242193754C105580179 @default.
• W4242193754 hasConceptScore W4242193754C109159458 @default.
• W4242193754 hasConceptScore W4242193754C153911025 @default.
• W4242193754 hasConceptScore W4242193754C203014093 @default.
• W4242193754 hasConceptScore W4242193754C2776958478 @default.
• W4242193754 hasConceptScore W4242193754C2777863708 @default.
• W4242193754 hasConceptScore W4242193754C2778713057 @default.
• W4242193754 hasConceptScore W4242193754C2778837598 @default.
• W4242193754 hasConceptScore W4242193754C2779705218 @default.
• W4242193754 hasConceptScore W4242193754C2781057849 @default.
• W4242193754 hasConceptScore W4242193754C28328180 @default.
• W4242193754 hasConceptScore W4242193754C501734568 @default.
• W4242193754 hasConceptScore W4242193754C502942594 @default.
• W4242193754 hasConceptScore W4242193754C54355233 @default.
• W4242193754 hasConceptScore W4242193754C86803240 @default.
• W4242193754 hasConceptScore W4242193754C89604277 @default.
• W4242193754 hasIssue "4" @default.
• W4242193754 hasLocation W42421937541 @default.
• W4242193754 hasOpenAccess W4242193754 @default.
• W4242193754 hasPrimaryLocation W42421937541 @default.
• W4242193754 hasRelatedWork W10844698 @default.
• W4242193754 hasRelatedWork W11494946 @default.
• W4242193754 hasRelatedWork W17414462 @default.

• next