Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242220066> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4242220066 abstract "Background Cardiac dysfunction after brain death has been documented, but its mechanisms remain unclear. Myocardial ischemia has been suggested as a possible cause. The aim of the present study was to investigate the existence of an imbalance between myocardial oxygen delivery and demand as a possible cause of myocardial dysfunction in brain-dead pigs. Methods and Results Interstitial myocardial lactate and adenosine concentrations were assessed with cardiac microdialysis in 2 groups of animals: brain-dead pigs (n=7) and brain-dead pigs treated with labetalol (10±3 mg/kg) (n=7). Heart rate (HR), left ventricular (LV) dP/dt max , rate-pressure product (RPP), cardiac output (CO), and left anterior descending coronary artery blood flow (QLAD) were continuously monitored. Brain-dead pigs exhibited a transient significant increase in HR, LV dP/dt max , RPP, and CO and a limited increase in QLAD. This resulted in functional myocardial ischemia attested to by the significantly increased adenosine and lactate microdialysate concentrations. In brain-dead pigs treated with labetalol, there was a moderate increase in HR, QLAD, and adenosine microdialysate concentrations; LV dP/dt max , RPP, CO, and myocardial lactate concentrations remained stable, confirming the preservation of aerobic metabolism. Conclusions Brain death was associated with an increase in myocardial interstitial adenosine and lactate concentrations, as well as with myocardial dysfunction; all were attenuated by labetalol, suggesting an imbalance between oxygen consumption and oxygen delivery as a possible cause of myocardial dysfunction after brain death." @default.
- W4242220066 created "2022-05-12" @default.
- W4242220066 creator A5014339458 @default.
- W4242220066 creator A5023687827 @default.
- W4242220066 creator A5024642494 @default.
- W4242220066 creator A5036821495 @default.
- W4242220066 creator A5052329481 @default.
- W4242220066 creator A5055004014 @default.
- W4242220066 creator A5062935124 @default.
- W4242220066 creator A5065823002 @default.
- W4242220066 creator A5070591447 @default.
- W4242220066 date "2001-09-18" @default.
- W4242220066 modified "2023-10-17" @default.
- W4242220066 title "Evidence of Functional Myocardial Ischemia Associated With Myocardial Dysfunction in Brain-Dead Pigs" @default.
- W4242220066 cites W1906305495 @default.
- W4242220066 cites W1965257695 @default.
- W4242220066 cites W1970545385 @default.
- W4242220066 cites W1976922801 @default.
- W4242220066 cites W1989692828 @default.
- W4242220066 cites W1996152902 @default.
- W4242220066 cites W1997260873 @default.
- W4242220066 cites W2011002099 @default.
- W4242220066 cites W2014174092 @default.
- W4242220066 cites W2017499635 @default.
- W4242220066 cites W2028362476 @default.
- W4242220066 cites W2051975549 @default.
- W4242220066 cites W2071310284 @default.
- W4242220066 cites W2157156552 @default.
- W4242220066 cites W2169117417 @default.
- W4242220066 cites W2421963703 @default.
- W4242220066 doi "https://doi.org/10.1161/circ.104.suppl_1.i-197" @default.
- W4242220066 hasPublicationYear "2001" @default.
- W4242220066 type Work @default.
- W4242220066 citedByCount "0" @default.
- W4242220066 crossrefType "journal-article" @default.
- W4242220066 hasAuthorship W4242220066A5014339458 @default.
- W4242220066 hasAuthorship W4242220066A5023687827 @default.
- W4242220066 hasAuthorship W4242220066A5024642494 @default.
- W4242220066 hasAuthorship W4242220066A5036821495 @default.
- W4242220066 hasAuthorship W4242220066A5052329481 @default.
- W4242220066 hasAuthorship W4242220066A5055004014 @default.
- W4242220066 hasAuthorship W4242220066A5062935124 @default.
- W4242220066 hasAuthorship W4242220066A5065823002 @default.
- W4242220066 hasAuthorship W4242220066A5070591447 @default.
- W4242220066 hasBestOaLocation W42422200661 @default.
- W4242220066 hasConcept C126322002 @default.
- W4242220066 hasConcept C164705383 @default.
- W4242220066 hasConcept C2775992611 @default.
- W4242220066 hasConcept C2776991684 @default.
- W4242220066 hasConcept C2777953023 @default.
- W4242220066 hasConcept C2777962398 @default.
- W4242220066 hasConcept C42219234 @default.
- W4242220066 hasConcept C50156730 @default.
- W4242220066 hasConcept C529278444 @default.
- W4242220066 hasConcept C541997718 @default.
- W4242220066 hasConcept C71924100 @default.
- W4242220066 hasConcept C84393581 @default.
- W4242220066 hasConceptScore W4242220066C126322002 @default.
- W4242220066 hasConceptScore W4242220066C164705383 @default.
- W4242220066 hasConceptScore W4242220066C2775992611 @default.
- W4242220066 hasConceptScore W4242220066C2776991684 @default.
- W4242220066 hasConceptScore W4242220066C2777953023 @default.
- W4242220066 hasConceptScore W4242220066C2777962398 @default.
- W4242220066 hasConceptScore W4242220066C42219234 @default.
- W4242220066 hasConceptScore W4242220066C50156730 @default.
- W4242220066 hasConceptScore W4242220066C529278444 @default.
- W4242220066 hasConceptScore W4242220066C541997718 @default.
- W4242220066 hasConceptScore W4242220066C71924100 @default.
- W4242220066 hasConceptScore W4242220066C84393581 @default.
- W4242220066 hasIssue "suppl_1" @default.
- W4242220066 hasLocation W42422200661 @default.
- W4242220066 hasOpenAccess W4242220066 @default.
- W4242220066 hasPrimaryLocation W42422200661 @default.
- W4242220066 hasRelatedWork W10082787 @default.
- W4242220066 hasRelatedWork W13247121 @default.
- W4242220066 hasRelatedWork W14376166 @default.
- W4242220066 hasRelatedWork W15334259 @default.
- W4242220066 hasRelatedWork W1716710 @default.
- W4242220066 hasRelatedWork W1911952 @default.
- W4242220066 hasRelatedWork W2725302 @default.
- W4242220066 hasRelatedWork W2741520 @default.
- W4242220066 hasRelatedWork W27570378 @default.
- W4242220066 hasRelatedWork W548565 @default.
- W4242220066 hasVolume "104" @default.
- W4242220066 isParatext "false" @default.
- W4242220066 isRetracted "false" @default.
- W4242220066 workType "article" @default.