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• W4242230785 abstract "Background Open angle glaucoma (OAG) is a common cause of blindness. Objectives To study the relative effects of medical and surgical treatment of OAG. Search methods We searched CENTRAL, MEDLINE, EMBASE, LILACS, BIOSIS, SIGLE, NRR, CINAHL, ZETOC to April 2007, reference lists of articles and also contacted researchers in the field. Selection criteria We included randomised controlled trials comparing medications with surgery in adults. Data collection and analysis Two authors independently assessed trial quality and extracted data. We contacted trial investigators for missing information. Main results Four trials involving 888 participants with previously untreated OAG were included. Surgery was Scheie's procedure in one trial and trabeculectomy in three trials. In three trials, primary medication was usually pilocarpine, in one trial a beta‐blocker. The most recent trial included participants with mild OAG. The risk of progressive visual field (VF) loss, after adjustment for cataract surgery, was not significantly different for medications compared with trabeculectomy (odds ratio (OR) 0.74; 95% CI 0.54 to 1.01). Trabeculectomy was associated with a higher risk of reduced visual acuity (OR 0.47, 95%% CI 0.31 to 0.74), and more eye discomfort than medication (P = 0.03). In more severe OAG there is some evidence, from three trials, that medication was associated with more progressive VF loss and 6 to 9 mmHg less intraocular pressure (IOP) lowering than surgery. In the longer‐term (two trials) the risk of failure of the randomised treatment was greater with medication than trabeculectomy (OR 3.90, 95% CI 1.60 to 9.53; HR 7.27, 95% CI 2.23 to 25.71). Medications and surgery have evolved since these trials were undertaken. In three trials the risk of developing cataract was higher with trabeculectomy (OR 2.69, 95%% CI 1.64 to 4.42). Methodological weaknesses were identified in all the trials. Authors' conclusions Evidence from one trial suggests, for mild OAG, that the risk of glaucoma progression up to five‐years is not significantly different whether treatment is initiated with medication or trabeculectomy. Reduced vision, cataract and eye discomfort are more likely with trabeculectomy. There is some evidence, for more severe OAG, that initial medication (pilocarpine, now rarely used as first line medication) is associated with a greater risk of glaucoma progression than surgery. Surgery lowers IOP more than medication. There was no evidence to determine the effectiveness of contemporary medication (prostaglandin analogues, alpha2‐agonists and topical carbonic anhydrase inhibitors) compared with surgery in severe OAG, and in people of black ethnicity. More research is required." @default.
• W4242230785 created "2022-05-12" @default.
• W4242230785 creator A5015146035 @default.
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• W4242230785 date "2004-04-19" @default.
• W4242230785 modified "2023-10-14" @default.
• W4242230785 title "Medical versus surgical interventions for open angle glaucoma" @default.
• W4242230785 cites W1002541839 @default.
• W4242230785 cites W125439001 @default.
• W4242230785 cites W138756786 @default.
• W4242230785 cites W1512270502 @default.
• W4242230785 cites W158364456 @default.
• W4242230785 cites W1584824855 @default.
• W4242230785 cites W1822075922 @default.
• W4242230785 cites W1898079050 @default.
• W4242230785 cites W1936542701 @default.
• W4242230785 cites W1964022954 @default.
• W4242230785 cites W1966661538 @default.
• W4242230785 cites W1967058915 @default.
• W4242230785 cites W1975287798 @default.
• W4242230785 cites W1976253654 @default.
• W4242230785 cites W1981070465 @default.
• W4242230785 cites W1981504117 @default.
• W4242230785 cites W1997878197 @default.
• W4242230785 cites W1999667582 @default.
• W4242230785 cites W2000989960 @default.
• W4242230785 cites W2001985437 @default.
• W4242230785 cites W2002911614 @default.
• W4242230785 cites W2003586642 @default.
• W4242230785 cites W2008785553 @default.
• W4242230785 cites W2018411837 @default.
• W4242230785 cites W2018895929 @default.
• W4242230785 cites W2020507502 @default.
• W4242230785 cites W2024577563 @default.
• W4242230785 cites W2026178775 @default.
• W4242230785 cites W2032749316 @default.
• W4242230785 cites W2033451677 @default.
• W4242230785 cites W2036280128 @default.
• W4242230785 cites W2038754493 @default.
• W4242230785 cites W2039070573 @default.
• W4242230785 cites W2041123138 @default.
• W4242230785 cites W2044153293 @default.
• W4242230785 cites W2060819029 @default.
• W4242230785 cites W2061581099 @default.
• W4242230785 cites W2064875406 @default.
• W4242230785 cites W2066103355 @default.
• W4242230785 cites W2068402134 @default.
• W4242230785 cites W2072088948 @default.
• W4242230785 cites W2073386740 @default.
• W4242230785 cites W2075599926 @default.
• W4242230785 cites W2075642745 @default.
• W4242230785 cites W2079302533 @default.
• W4242230785 cites W2092323590 @default.
• W4242230785 cites W2093882390 @default.
• W4242230785 cites W2094273610 @default.
• W4242230785 cites W2100556262 @default.
• W4242230785 cites W2108773276 @default.
• W4242230785 cites W2110897487 @default.
• W4242230785 cites W2123977931 @default.
• W4242230785 cites W2131138564 @default.
• W4242230785 cites W2137221550 @default.
• W4242230785 cites W2139077400 @default.
• W4242230785 cites W2140594570 @default.
• W4242230785 cites W2144936386 @default.
• W4242230785 cites W2145074796 @default.
• W4242230785 cites W2147213528 @default.
• W4242230785 cites W2148498477 @default.
• W4242230785 cites W2148890166 @default.
• W4242230785 cites W2152239032 @default.
• W4242230785 cites W2157890401 @default.
• W4242230785 cites W2161747007 @default.
• W4242230785 cites W2167025827 @default.
• W4242230785 cites W2276375362 @default.
• W4242230785 cites W2314575875 @default.
• W4242230785 cites W2616044243 @default.
• W4242230785 cites W2625521663 @default.
• W4242230785 cites W4250039173 @default.
• W4242230785 cites W4293101293 @default.
• W4242230785 doi "https://doi.org/10.1002/14651858.cd004399.pub2" @default.
• W4242230785 hasPublicationYear "2004" @default.
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