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- W4242349676 abstract "Numerous proteins regulate gene expression by modulating mRNA translation and decay. In order to uncover the full scope of these post-transcriptional regulators, we conducted an unbiased survey that quantifies regulatory activity across the budding yeast proteome and delineates the protein domains responsible for these effects. Our approach couples a tethered function assay with quantitative single-cell fluorescence measurements to analyze ∼50,000 protein fragments and determine their effects on a tethered mRNA. We characterize hundreds of strong regulators, which are enriched for canonical and unconventional mRNA-binding proteins. Regulatory activity typically maps outside the RNA-binding domains themselves, highlighting a modular architecture that separates mRNA targeting from post-transcriptional regulation. Activity often aligns with intrinsically disordered regions that can interact with other proteins, even in core mRNA translation and degradation factors. Our results thus reveal networks of interacting proteins that control mRNA fate and illuminate the molecular basis for post-transcriptional gene regulation." @default.
- W4242349676 created "2022-05-12" @default.
- W4242349676 creator A5016282453 @default.
- W4242349676 creator A5022305496 @default.
- W4242349676 creator A5059700078 @default.
- W4242349676 creator A5062834012 @default.
- W4242349676 creator A5090965613 @default.
- W4242349676 date "2021-08-09" @default.
- W4242349676 modified "2023-09-27" @default.
- W4242349676 title "Surveying the global landscape of post-transcriptional regulators" @default.
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