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- W4242357872 abstract "Abstract Introduction Craniosynostosis is characterised by the premature fusion of cranial sutures. This can be associated with raised intracranial pressure (ICP), which can lead to developmental delay, visual impairment and death. Treatment involves surgical expansion of the skull vault. There is no consensus over who to treat and when. Intracranial pressure is difficult to estimate in a child and existing methods possess sub-optimal diagnostic accuracy to be employed as screening tools. Here, we propose a systematic review protocol to examine the role of optical coherence tomography (OCT) in early detection of raised ICP in craniosynostosis. Methods Electronic searches in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and Embase will identify studies featuring OCT in detecting raised ICP in children with craniosynostosis. Two independent researchers will identify studies for inclusion using a screening questionnaire. Quality will be assessed using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. The primary outcome measure is the sensitivity and specificity of OCT in detecting raised ICP in children with craniosynostosis. Secondary outcomes measures include the sensitivity and specificity of other surrogate measures for raised ICP, OCT parameters used and normal ranges for ICP reported. A formal narrative synthesis with descriptive statistics will be presented. Discussion The proposed study will be the first to examine the role of optical coherence tomography in the early recognition of raised intracranial pressure in craniosynostosis, thereby addressing an important clinical problem in paediatric ophthalmology and craniofacial surgery. This systematic review protocol provides transparency to the proposed methods and reduces the possibility of duplication. The proposed methods reflect those prescribed by the Cochrane Collaboration. Systematic review registration International Prospective Register for Systematic Reviews (PROSPERO) number CRD42019147693" @default.
- W4242357872 created "2022-05-12" @default.
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- W4242357872 date "2020-02-04" @default.
- W4242357872 modified "2023-09-24" @default.
- W4242357872 title "Detection of Raised Intracranial Pressure in Craniosynostosis using Optical Coherence Tomography: A Systematic Review Protocol" @default.
- W4242357872 doi "https://doi.org/10.21203/rs.2.22649/v1" @default.
- W4242357872 hasPublicationYear "2020" @default.
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