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- W4242534835 abstract "Nitric oxide (NO), synthesized from the amino acid l-arginine by NO synthases, is a unique type of transmitter in the nervous system. In the central nervous system, generation of NO is frequently coupled to activation of the NMDA class of glutamate receptor. Once produced, NO diffuses rapidly across membranes to act on neighboring cells, its principal receptors being specialized guanylyl cyclase-coupled proteins. The receptors are tuned to detect subnanomolar concentrations of NO and rapidly transduce them into micromolar concentrations of cyclic GMP. This pathway participates in numerous physiological functions, including synaptic plasticity. Through other mechanisms, NO may contribute to neuropathology." @default.
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- W4242534835 date "2009-01-01" @default.
- W4242534835 modified "2023-10-17" @default.
- W4242534835 title "Nitric Oxide" @default.
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- W4242534835 doi "https://doi.org/10.1016/b978-008045046-9.00684-7" @default.
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