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- W4242541350 abstract "The region and mechanism of urinary protein C inhibitor (PCI) binding to fibrin(ogen) were examined using fibrin(ogen)-Sepharose and ligand blotting. Urinary PCI bound to fibrin(ogen)-Sepharose in a heparin-dependent manner at a level about 1.6-fold higher to fibrin-Sepharose than to fibrinogen-Sepharose. Scatchard analysis of the binding between urinary PCI and fibrin(ogen)-Sepharose showed that the Kd for fibrin-Sepharose and fibrinogen-Sepharose were 4.0 nM and 5.7 nM respectively. Ligand blotting using urinary PCI and an enzyme-linked immunoassay showed that urinary PCI bound to fibrinogen, fibrinogen degradation products (X, Y, D and E) and the Aα-, Bβ- and ρ-chains of fibrinogen. Binding between urinary PCI and fibrin(ogen)-Sepharose was slightly suppressed (16%) by α-methylmannose and largely suppressed (42%) by EACA, which indicates that the carbohydrate chain and the lysine binding site participate in the binding. These findings suggest that urinary PCI binds to fibrin(ogen) via the Aα-, Bβ- and ρ-chains and its binding is partly mediated by carbohydrate and the lysine binding site." @default.
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- W4242541350 date "1993-02-01" @default.
- W4242541350 modified "2023-09-30" @default.
- W4242541350 title "Binding of urinary protein C inhibitor to fibrin(ogen) and its binding mechanism" @default.
- W4242541350 doi "https://doi.org/10.1097/00001721-199304010-00027" @default.
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