Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242575897> ?p ?o ?g. }
- W4242575897 endingPage "117739280700200" @default.
- W4242575897 startingPage "117739280700200" @default.
- W4242575897 abstract "Some systemic rheumatic diseases and disorders, especially fibrotic and vascular disorders, are often refractory to corticosteroid therapy. Recently, ever accumulating evidence suggests that platelet-derived growth factor (PDGF) is involved in those refractory diseases. Imatinib mesylate inhibits the activation of PDGF receptor as well as c-Abl, Bcr-Abl and c-Kit tyrosine kinases. It has therefore been widely used for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors. Imatinib effectively suppresses the activation and proliferation of fibroblasts, mesangial cells and smooth muscle cells both in vitro and in vivo. Additionally, it has recently been reported that some patients with rheumatoid arthritis or idiopathic pulmonary arterial hypertension demonstrated a good clinical response to imatinib therapy. Imatinib may therefore overcome the limitations of current therapeutic strategy with corticosteroids and immunosuppressive agents for refractory diseases, such as systemic sclerosis and interstitial lung diseases, without clinical intolerability." @default.
- W4242575897 created "2022-05-12" @default.
- W4242575897 creator A5000620804 @default.
- W4242575897 creator A5058629132 @default.
- W4242575897 creator A5083314956 @default.
- W4242575897 date "2007-01-01" @default.
- W4242575897 modified "2023-09-23" @default.
- W4242575897 title "Platelet-Derived Growth Factor as a Therapeutic Target for Systemic Autoimmune Diseases" @default.
- W4242575897 cites W1537640166 @default.
- W4242575897 cites W1556322054 @default.
- W4242575897 cites W1970412834 @default.
- W4242575897 cites W1970709922 @default.
- W4242575897 cites W1972644785 @default.
- W4242575897 cites W1978166197 @default.
- W4242575897 cites W1983203756 @default.
- W4242575897 cites W1985196248 @default.
- W4242575897 cites W1986569175 @default.
- W4242575897 cites W2003940493 @default.
- W4242575897 cites W2013920567 @default.
- W4242575897 cites W2015015957 @default.
- W4242575897 cites W2016086822 @default.
- W4242575897 cites W2029795839 @default.
- W4242575897 cites W2032383027 @default.
- W4242575897 cites W2034991196 @default.
- W4242575897 cites W2036199559 @default.
- W4242575897 cites W2037178677 @default.
- W4242575897 cites W2045375116 @default.
- W4242575897 cites W2051747444 @default.
- W4242575897 cites W2055865775 @default.
- W4242575897 cites W2056747448 @default.
- W4242575897 cites W2063023628 @default.
- W4242575897 cites W2064346042 @default.
- W4242575897 cites W2066165267 @default.
- W4242575897 cites W2066904629 @default.
- W4242575897 cites W2071636984 @default.
- W4242575897 cites W2074997189 @default.
- W4242575897 cites W2085182558 @default.
- W4242575897 cites W2085626592 @default.
- W4242575897 cites W2087457069 @default.
- W4242575897 cites W2106797092 @default.
- W4242575897 cites W2110121929 @default.
- W4242575897 cites W2111791469 @default.
- W4242575897 cites W2112302625 @default.
- W4242575897 cites W2124106442 @default.
- W4242575897 cites W2131862721 @default.
- W4242575897 cites W2132346873 @default.
- W4242575897 cites W2132978366 @default.
- W4242575897 cites W2138286374 @default.
- W4242575897 cites W2139352577 @default.
- W4242575897 cites W2141138459 @default.
- W4242575897 cites W2147944062 @default.
- W4242575897 cites W2150271837 @default.
- W4242575897 cites W2156807514 @default.
- W4242575897 cites W2160448039 @default.
- W4242575897 cites W2162525969 @default.
- W4242575897 cites W2312804644 @default.
- W4242575897 cites W2316322580 @default.
- W4242575897 cites W2329648702 @default.
- W4242575897 cites W2329872528 @default.
- W4242575897 cites W2336588424 @default.
- W4242575897 cites W2416914730 @default.
- W4242575897 cites W2626588662 @default.
- W4242575897 cites W4248663651 @default.
- W4242575897 cites W4255779404 @default.
- W4242575897 doi "https://doi.org/10.1177/117739280700200006" @default.
- W4242575897 hasPublicationYear "2007" @default.
- W4242575897 type Work @default.
- W4242575897 citedByCount "6" @default.
- W4242575897 countsByYear W42425758972018 @default.
- W4242575897 countsByYear W42425758972020 @default.
- W4242575897 countsByYear W42425758972021 @default.
- W4242575897 countsByYear W42425758972022 @default.
- W4242575897 countsByYear W42425758972023 @default.
- W4242575897 crossrefType "journal-article" @default.
- W4242575897 hasAuthorship W4242575897A5000620804 @default.
- W4242575897 hasAuthorship W4242575897A5058629132 @default.
- W4242575897 hasAuthorship W4242575897A5083314956 @default.
- W4242575897 hasBestOaLocation W42425758971 @default.
- W4242575897 hasConcept C126322002 @default.
- W4242575897 hasConcept C170493617 @default.
- W4242575897 hasConcept C180361614 @default.
- W4242575897 hasConcept C203014093 @default.
- W4242575897 hasConcept C2775960820 @default.
- W4242575897 hasConcept C2777575956 @default.
- W4242575897 hasConcept C2777583451 @default.
- W4242575897 hasConcept C2778729363 @default.
- W4242575897 hasConcept C2780007613 @default.
- W4242575897 hasConcept C2780581156 @default.
- W4242575897 hasConcept C2781294074 @default.
- W4242575897 hasConcept C3019892230 @default.
- W4242575897 hasConcept C42362537 @default.
- W4242575897 hasConcept C502942594 @default.
- W4242575897 hasConcept C71924100 @default.
- W4242575897 hasConceptScore W4242575897C126322002 @default.
- W4242575897 hasConceptScore W4242575897C170493617 @default.
- W4242575897 hasConceptScore W4242575897C180361614 @default.
- W4242575897 hasConceptScore W4242575897C203014093 @default.
- W4242575897 hasConceptScore W4242575897C2775960820 @default.