Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242648074> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4242648074 abstract "<div>The self-assembly of nanometric structures from molecular building blocks is an effective</div><div>way to make new functional materials for biological and technological applications. In this work</div><div>four symmetrical bolaamphiphiles based on dehydrodipeptides</div><div>(phenylalanyldehydrophenylalanine and tyrosyldehydrophenylalanine) linked through phenyl</div><div>or naphthyl linkers (terephthalic acid and 2,6-naphthalenedicarboxylic acid) were prepared and</div><div>their self-assembly properties studied. The results showed that all compounds with the exception</div><div>of the bolaamphiphile of tyrosyldehydrophenylalanine and 2,6-naphthalene dicarboxylic acid</div><div>gave self-standing hydrogels with critical gelation concentrations of 0.3 and 0.4 wt% using a pH</div><div>trigger. The self-assembly of these hydrogelators was investigated using STEM microscopy,</div><div>which revealed a network of entangled fibres. According to rheology the dehydrodipeptide</div><div>bolaamphiphile hydrogelators are viscoelastic materials with an elastic modulus G’ that falls in</div><div>the range of native tissue (0.37 kPa brain – 4.5 kPa cartilage). In viability and proliferation studies,</div><div>it was found that these compounds were non-toxic towards the human keratinocyte cell line,</div><div>HaCaT. In sustained release assays, we studied the effects of the charge present on the model</div><div>drug compound on the rate of cargo release from the hydrogel networks. Methylene blue (MB),</div><div>methyl orange (MO) and ciprofloxacin were chosen as cationic, anionic and overall neutral cargo,</div><div>respectively. These studies have shown that the hydrogels provide a sustained release of methyl</div><div>orange and ciprofloxacin, while the methylene blue is retained by the hydrogel network.</div>" @default.
- W4242648074 created "2022-05-12" @default.
- W4242648074 creator A5011882866 @default.
- W4242648074 creator A5029537737 @default.
- W4242648074 creator A5031810675 @default.
- W4242648074 creator A5034654118 @default.
- W4242648074 creator A5038676063 @default.
- W4242648074 creator A5062253561 @default.
- W4242648074 creator A5068790285 @default.
- W4242648074 creator A5071356790 @default.
- W4242648074 creator A5079517416 @default.
- W4242648074 date "2021-03-23" @default.
- W4242648074 modified "2023-09-29" @default.
- W4242648074 title "Bolaamphiphilic Bis-Dehydropeptide Hydrogels as Potential Drug Release Systems" @default.
- W4242648074 doi "https://doi.org/10.26434/chemrxiv.14261903.v1" @default.
- W4242648074 hasPublicationYear "2021" @default.
- W4242648074 type Work @default.
- W4242648074 citedByCount "0" @default.
- W4242648074 crossrefType "posted-content" @default.
- W4242648074 hasAuthorship W4242648074A5011882866 @default.
- W4242648074 hasAuthorship W4242648074A5029537737 @default.
- W4242648074 hasAuthorship W4242648074A5031810675 @default.
- W4242648074 hasAuthorship W4242648074A5034654118 @default.
- W4242648074 hasAuthorship W4242648074A5038676063 @default.
- W4242648074 hasAuthorship W4242648074A5062253561 @default.
- W4242648074 hasAuthorship W4242648074A5068790285 @default.
- W4242648074 hasAuthorship W4242648074A5071356790 @default.
- W4242648074 hasAuthorship W4242648074A5079517416 @default.
- W4242648074 hasBestOaLocation W42426480741 @default.
- W4242648074 hasConcept C108586683 @default.
- W4242648074 hasConcept C118995209 @default.
- W4242648074 hasConcept C119394753 @default.
- W4242648074 hasConcept C178790620 @default.
- W4242648074 hasConcept C185592680 @default.
- W4242648074 hasConcept C202751555 @default.
- W4242648074 hasConcept C2777516009 @default.
- W4242648074 hasConcept C2780330708 @default.
- W4242648074 hasConcept C55493867 @default.
- W4242648074 hasConcept C71240020 @default.
- W4242648074 hasConceptScore W4242648074C108586683 @default.
- W4242648074 hasConceptScore W4242648074C118995209 @default.
- W4242648074 hasConceptScore W4242648074C119394753 @default.
- W4242648074 hasConceptScore W4242648074C178790620 @default.
- W4242648074 hasConceptScore W4242648074C185592680 @default.
- W4242648074 hasConceptScore W4242648074C202751555 @default.
- W4242648074 hasConceptScore W4242648074C2777516009 @default.
- W4242648074 hasConceptScore W4242648074C2780330708 @default.
- W4242648074 hasConceptScore W4242648074C55493867 @default.
- W4242648074 hasConceptScore W4242648074C71240020 @default.
- W4242648074 hasLocation W42426480741 @default.
- W4242648074 hasLocation W42426480742 @default.
- W4242648074 hasOpenAccess W4242648074 @default.
- W4242648074 hasPrimaryLocation W42426480741 @default.
- W4242648074 hasRelatedWork W1974737688 @default.
- W4242648074 hasRelatedWork W1981674383 @default.
- W4242648074 hasRelatedWork W2005048320 @default.
- W4242648074 hasRelatedWork W2007258996 @default.
- W4242648074 hasRelatedWork W2009575279 @default.
- W4242648074 hasRelatedWork W2017828621 @default.
- W4242648074 hasRelatedWork W2075183115 @default.
- W4242648074 hasRelatedWork W2946435487 @default.
- W4242648074 hasRelatedWork W2985076304 @default.
- W4242648074 hasRelatedWork W617474620 @default.
- W4242648074 isParatext "false" @default.
- W4242648074 isRetracted "false" @default.
- W4242648074 workType "article" @default.