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- W4242722974 abstract "In this chapter we discuss the factors that need to be considered in the design of API for inhalation. The objective of an inhaled drug is to achieve an efficacious dose in the lung for a prolonged period whilst minimizing systemic exposure and consequent side-effects. We show that marketed inhaled agents have properties well outside those typical for oral drugs. It is necessary to understand the processes involved in drug action in the lung, the distribution, dissolution and disposition of the inhaled molecule as well as the site of the intended target. The properties of the inhaled agent are typically affected by the type of molecule being administered and we show how four different strategies have been applied to obtain extended duration of action in the lung, that is to say by slow dissolution of the API, modulation of permeability, tissue binding and design of lung-specific prodrugs." @default.
- W4242722974 created "2022-05-12" @default.
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- W4242722974 date "2021-01-01" @default.
- W4242722974 modified "2023-10-16" @default.
- W4242722974 title "The API" @default.
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- W4242722974 doi "https://doi.org/10.1016/b978-0-12-814974-4.00006-7" @default.
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