Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242728298> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4242728298 endingPage "398" @default.
- W4242728298 startingPage "389" @default.
- W4242728298 abstract "New, non-imidazole histamine H3 receptor antagonists were prepared and in vitro tested as H3 receptor antagonists measured as the electrically evoked contraction of the guinea-pig jejunum. The 2-(1-piperidinyl)- and 2-(1-pyrrolidinyl)benzothiazoles show no or very poor activity; 2-[1-(4-amino)piperidinyl]- and 2-(1,2-ethanediamino)- and 2-(1,3-propanediamino)derivatives of benzothiazole possess weak activity at H3 receptors, whereas 2-(4-piperidinyl)benzothiazoles and 2-[1-(4-piperazinyl)]benzothiazoles show moderate to good activity. Lipophilic and not-too-bulky substituents like n-propyl attached to the nitrogen at the piperazine or piperidine ring lead to potent H3 receptor antagonists with pA2 values ranging from 7.0 to 7.2. The structure-activity relationships for different substitution patterns are discussed." @default.
- W4242728298 created "2022-05-12" @default.
- W4242728298 creator A5004659647 @default.
- W4242728298 creator A5025539425 @default.
- W4242728298 creator A5060766928 @default.
- W4242728298 creator A5078611730 @default.
- W4242728298 date "1999-11-01" @default.
- W4242728298 modified "2023-09-23" @default.
- W4242728298 title "Non-Imidazole Histamine H3 Ligands, Part 2: New 2-Substituted Benzothiazoles as Histamine H3 Antagonists" @default.
- W4242728298 doi "https://doi.org/10.1002/(sici)1521-4184(199911)332:11<389::aid-ardp389>3.3.co;2-l" @default.
- W4242728298 hasPublicationYear "1999" @default.
- W4242728298 type Work @default.
- W4242728298 citedByCount "2" @default.
- W4242728298 crossrefType "journal-article" @default.
- W4242728298 hasAuthorship W4242728298A5004659647 @default.
- W4242728298 hasAuthorship W4242728298A5025539425 @default.
- W4242728298 hasAuthorship W4242728298A5060766928 @default.
- W4242728298 hasAuthorship W4242728298A5078611730 @default.
- W4242728298 hasConcept C1122143 @default.
- W4242728298 hasConcept C134018914 @default.
- W4242728298 hasConcept C159545944 @default.
- W4242728298 hasConcept C163415756 @default.
- W4242728298 hasConcept C170493617 @default.
- W4242728298 hasConcept C178790620 @default.
- W4242728298 hasConcept C185592680 @default.
- W4242728298 hasConcept C2776201271 @default.
- W4242728298 hasConcept C2776885963 @default.
- W4242728298 hasConcept C2777456753 @default.
- W4242728298 hasConcept C2780874372 @default.
- W4242728298 hasConcept C2781462491 @default.
- W4242728298 hasConcept C55493867 @default.
- W4242728298 hasConcept C63180777 @default.
- W4242728298 hasConcept C71240020 @default.
- W4242728298 hasConcept C86803240 @default.
- W4242728298 hasConcept C98274493 @default.
- W4242728298 hasConceptScore W4242728298C1122143 @default.
- W4242728298 hasConceptScore W4242728298C134018914 @default.
- W4242728298 hasConceptScore W4242728298C159545944 @default.
- W4242728298 hasConceptScore W4242728298C163415756 @default.
- W4242728298 hasConceptScore W4242728298C170493617 @default.
- W4242728298 hasConceptScore W4242728298C178790620 @default.
- W4242728298 hasConceptScore W4242728298C185592680 @default.
- W4242728298 hasConceptScore W4242728298C2776201271 @default.
- W4242728298 hasConceptScore W4242728298C2776885963 @default.
- W4242728298 hasConceptScore W4242728298C2777456753 @default.
- W4242728298 hasConceptScore W4242728298C2780874372 @default.
- W4242728298 hasConceptScore W4242728298C2781462491 @default.
- W4242728298 hasConceptScore W4242728298C55493867 @default.
- W4242728298 hasConceptScore W4242728298C63180777 @default.
- W4242728298 hasConceptScore W4242728298C71240020 @default.
- W4242728298 hasConceptScore W4242728298C86803240 @default.
- W4242728298 hasConceptScore W4242728298C98274493 @default.
- W4242728298 hasIssue "11" @default.
- W4242728298 hasLocation W42427282981 @default.
- W4242728298 hasOpenAccess W4242728298 @default.
- W4242728298 hasPrimaryLocation W42427282981 @default.
- W4242728298 hasRelatedWork W1980791114 @default.
- W4242728298 hasRelatedWork W1990684054 @default.
- W4242728298 hasRelatedWork W2002922470 @default.
- W4242728298 hasRelatedWork W2057376166 @default.
- W4242728298 hasRelatedWork W2103959619 @default.
- W4242728298 hasRelatedWork W2407812270 @default.
- W4242728298 hasRelatedWork W2522836974 @default.
- W4242728298 hasRelatedWork W2909461677 @default.
- W4242728298 hasRelatedWork W2966096459 @default.
- W4242728298 hasRelatedWork W4242728298 @default.
- W4242728298 hasVolume "332" @default.
- W4242728298 isParatext "false" @default.
- W4242728298 isRetracted "false" @default.
- W4242728298 workType "article" @default.