Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242766260> ?p ?o ?g. }
- W4242766260 endingPage "361" @default.
- W4242766260 startingPage "351" @default.
- W4242766260 abstract "Abstract We investigated the role of 4-1BB, a T cell co-stimulatory molecule, in alloimmune responses. In vivo mixed lymphocyte reactions showed that 4-1BB was preferentially expressed on actively dividing CD4+ and CD8+ T cells. Furthermore, following alloantigen challenge, the draining lymph nodes contained subpopulations of 4-1BB-expressing CD4+ and CD8+ T cells. 4-1BB-deficient C57BL/6 mice showed a delayed rejection of cardiac transplants mismatched for the major histocompatibility complex. Longer transplant survival was induced by blockade of 4-1BB/4-1BB ligand (4-1BBL) interactions using an anti-4-1BBL monoclonal antibody. Histological analysis showed that prolonged transplant survival in the 4-1BB-deficient and anti-4-1BBL-treated mice correlated with reduced lymphocytic infiltration and vasculitis in the donor heart tissue. Taken together, our data suggest that blockade of 4-1BB/4-1BBL interactions inhibited the expansion of alloreactive T cells and reduced CTL activity against host alloantigen, which in turn resulted in the prolongation of allograft survival. Blockade of the 4-1BB co-stimulatory pathway may be useful for preventing allograft rejection." @default.
- W4242766260 created "2022-05-12" @default.
- W4242766260 creator A5000300101 @default.
- W4242766260 creator A5009371940 @default.
- W4242766260 creator A5011979031 @default.
- W4242766260 creator A5018945257 @default.
- W4242766260 creator A5026853110 @default.
- W4242766260 creator A5030383968 @default.
- W4242766260 creator A5031487402 @default.
- W4242766260 creator A5033184942 @default.
- W4242766260 creator A5043877526 @default.
- W4242766260 creator A5061500160 @default.
- W4242766260 creator A5070494006 @default.
- W4242766260 creator A5071728483 @default.
- W4242766260 creator A5088986458 @default.
- W4242766260 creator A5090770301 @default.
- W4242766260 date "2004-08-01" @default.
- W4242766260 modified "2023-10-14" @default.
- W4242766260 title "Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival" @default.
- W4242766260 cites W1482617484 @default.
- W4242766260 cites W1483299903 @default.
- W4242766260 cites W1487003048 @default.
- W4242766260 cites W1492642877 @default.
- W4242766260 cites W1499068539 @default.
- W4242766260 cites W1502844719 @default.
- W4242766260 cites W1508314971 @default.
- W4242766260 cites W1517571699 @default.
- W4242766260 cites W1524274652 @default.
- W4242766260 cites W1605178114 @default.
- W4242766260 cites W1630218117 @default.
- W4242766260 cites W1846571856 @default.
- W4242766260 cites W1975060729 @default.
- W4242766260 cites W1979716786 @default.
- W4242766260 cites W1991385476 @default.
- W4242766260 cites W1998006783 @default.
- W4242766260 cites W2004159506 @default.
- W4242766260 cites W2005639428 @default.
- W4242766260 cites W2009826154 @default.
- W4242766260 cites W2013165543 @default.
- W4242766260 cites W2014452295 @default.
- W4242766260 cites W2028832240 @default.
- W4242766260 cites W2044166736 @default.
- W4242766260 cites W2054083392 @default.
- W4242766260 cites W2057127443 @default.
- W4242766260 cites W2062610658 @default.
- W4242766260 cites W2067846827 @default.
- W4242766260 cites W2099241614 @default.
- W4242766260 cites W2124458350 @default.
- W4242766260 cites W2132486642 @default.
- W4242766260 cites W2134779076 @default.
- W4242766260 cites W2153519961 @default.
- W4242766260 cites W2156843873 @default.
- W4242766260 cites W2157620455 @default.
- W4242766260 cites W2163571135 @default.
- W4242766260 cites W2167153348 @default.
- W4242766260 cites W2362891015 @default.
- W4242766260 cites W4235175787 @default.
- W4242766260 cites W4241646216 @default.
- W4242766260 cites W4245459124 @default.
- W4242766260 cites W4247924043 @default.
- W4242766260 doi "https://doi.org/10.1111/j.1432-2277.2004.tb00454.x" @default.
- W4242766260 hasPublicationYear "2004" @default.
- W4242766260 type Work @default.
- W4242766260 citedByCount "38" @default.
- W4242766260 countsByYear W42427662602012 @default.
- W4242766260 countsByYear W42427662602013 @default.
- W4242766260 countsByYear W42427662602014 @default.
- W4242766260 countsByYear W42427662602015 @default.
- W4242766260 countsByYear W42427662602017 @default.
- W4242766260 countsByYear W42427662602019 @default.
- W4242766260 countsByYear W42427662602021 @default.
- W4242766260 crossrefType "journal-article" @default.
- W4242766260 hasAuthorship W4242766260A5000300101 @default.
- W4242766260 hasAuthorship W4242766260A5009371940 @default.
- W4242766260 hasAuthorship W4242766260A5011979031 @default.
- W4242766260 hasAuthorship W4242766260A5018945257 @default.
- W4242766260 hasAuthorship W4242766260A5026853110 @default.
- W4242766260 hasAuthorship W4242766260A5030383968 @default.
- W4242766260 hasAuthorship W4242766260A5031487402 @default.
- W4242766260 hasAuthorship W4242766260A5033184942 @default.
- W4242766260 hasAuthorship W4242766260A5043877526 @default.
- W4242766260 hasAuthorship W4242766260A5061500160 @default.
- W4242766260 hasAuthorship W4242766260A5070494006 @default.
- W4242766260 hasAuthorship W4242766260A5071728483 @default.
- W4242766260 hasAuthorship W4242766260A5088986458 @default.
- W4242766260 hasAuthorship W4242766260A5090770301 @default.
- W4242766260 hasConcept C126322002 @default.
- W4242766260 hasConcept C147969180 @default.
- W4242766260 hasConcept C148125776 @default.
- W4242766260 hasConcept C167672396 @default.
- W4242766260 hasConcept C170493617 @default.
- W4242766260 hasConcept C203014093 @default.
- W4242766260 hasConcept C2776090121 @default.
- W4242766260 hasConcept C2778468042 @default.
- W4242766260 hasConcept C2778740727 @default.
- W4242766260 hasConcept C2780249625 @default.
- W4242766260 hasConcept C2780405999 @default.
- W4242766260 hasConcept C502942594 @default.