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- W4242768120 abstract "The use of fluorine as a surrogate for hydrogen and/or a hydroxyl group in synthetic nucleoside analogues has proved to be invaluable in the discovery of exciting new drug agents with novel biochemical properties. Being the most electronegative atom of all nonmetals, fluorine exerts distinct effects on nearly all structural elements in nucleosides and these effects are highly dependent on both the region and the stereochemistry of the fluorine substitution. Despite the dramatic influence that fluorine incorporation often has on the conformational and pharmacological properties of nucleoside analogues, there is a relatively small community of research groups that study the structural effects of fluorine substitution in detail. This review will concentrate on the current research on these effects, paying particular attention to fluorine substitution in the furanose portion of both nucleoside and nucleotide analogues." @default.
- W4242768120 created "2022-05-12" @default.
- W4242768120 creator A5074737138 @default.
- W4242768120 date "2009-01-01" @default.
- W4242768120 modified "2023-09-26" @default.
- W4242768120 title "Structural Studies of Biologically Interesting Fluorinated Nucleosides" @default.
- W4242768120 doi "https://doi.org/10.1021/bk-2009-1003.ch011" @default.
- W4242768120 hasPublicationYear "2009" @default.
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