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- W4242789805 abstract "Abstract Background: Medicine purchasing in Chinese public hospitals is decided by the hospital Pharmacy Management Committee (PMC), that is complex, subjective and requires efficient methods to ensure transparency and consistency for the factors being considered. This study aimed to use the Evidence and Value: Impact on Decision Making (EVIDEM) framework to assess medicine in these hospitals. In this study anti-diabetic drugs DPP-4 inhibitors, which work by inhibiting the activation of the Dipeptidyl Peptidase 4 (DPP-4) inhibitors, were appraised.Methods: Following EVIDEM methodology, we convened an appraisal group and asked each individual to express their perspectives by assigning weights to each criterion. A systematic literature search for information of each criterion of five DPP-4 inhibitors was completed. Then the appraisal group scored for each criterion of the five DPP-4 inhibitors. The estimated value of the five DPP-4 inhibitors was obtained by Multi-Criteria Decision Analysis (MCDA) which combined individual weighting of each criterion with individual scoring for each intervention in each criterion.Results: By assigning weights, the most important criterion was the quality of evidence (4.01±0.52), and that the comparative cost consequences-non-medical cost had lowest weight (2.87±1.03). Criteria included disease severity, size of the affected population, comparative effectiveness, type of therapeutic/preventive benefit and cost of intervention, all of which were assigned the same weight of 3.58. After MCDA, the overall value orders for each DPP-4 inhibitor included Sitagliptin (0.45), Linagliptin (0.44), Vildagliptin (0.43), Alogliptin (0.42) and Saxagliptin (0.40).Conclusions: Based on EVIDEM framework and MCDA, we found that overall value of five DPP-4 inhibitors was similar. it is feasible to use the EVIDEM framework and MCDA in purchasing medicine for Chinese public hospitals." @default.
- W4242789805 created "2022-05-12" @default.
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- W4242789805 date "2020-10-15" @default.
- W4242789805 modified "2023-09-25" @default.
- W4242789805 title "Impact on Decision Making Framework for Medicine Purchasing in Chinese Public Hospital Decision-making: Determining the Value of Five Dipeptidyl Peptidase 4 (DPP-4) inhibitors" @default.
- W4242789805 doi "https://doi.org/10.21203/rs.3.rs-35171/v2" @default.
- W4242789805 hasPublicationYear "2020" @default.
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