Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242800605> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4242800605 endingPage "S72" @default.
- W4242800605 startingPage "S72" @default.
- W4242800605 abstract "The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. l-Tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive nitrogen intermediates to form 3-nitrotyrosine (3-NT). Activated macrophages produce superoxide (O2·-) and NO, which are converted to peroxynitrite ONO2-. 3-NT formation is also catalyzed by a class of peroxidases utilizing nitrite and hydrogen peroxide as substrates. Evidence supports the formation of 3-NT in vivo in diverse pathologic conditions and 3-NT is thought to be a relatively specific marker of oxidative damage mediated by peroxynitrite. Free/protein-bound tyrosines are attacked by various RNS, including peroxynitrite, to form free/protein-bound 3-NT, which may provide insight into the etiopathogenesis of autoimmune conditions. The formation of nitrotyrosine represents a specific peroxynitrite-mediated protein modification; thus, detection of nitrotyrosine in proteins is considered as a biomarker for endogenous peroxynitrite activity. The peroxynitrite-driven oxidation and nitration of biomolecules may lead to autoimmune diseases such as systemic lupus. The subsequent release of altered proteins may enable them to act as antigen-inducing antibodies against self-proteins. Hence, tyrosine nitrated proteins can act as neoantigens and lead to the generation of autoantibodies against self proteins in various autoimmune disorders." @default.
- W4242800605 created "2022-05-12" @default.
- W4242800605 date "1999-01-01" @default.
- W4242800605 modified "2023-09-26" @default.
- W4242800605 title "Chronic moderate alcohol consumption results in induction of nitric oxide synthase and cardio-vascular protection" @default.
- W4242800605 doi "https://doi.org/10.1016/s0891-5849(99)90741-4" @default.
- W4242800605 hasPublicationYear "1999" @default.
- W4242800605 type Work @default.
- W4242800605 citedByCount "1" @default.
- W4242800605 crossrefType "journal-article" @default.
- W4242800605 hasConcept C159654299 @default.
- W4242800605 hasConcept C163764329 @default.
- W4242800605 hasConcept C178790620 @default.
- W4242800605 hasConcept C181199279 @default.
- W4242800605 hasConcept C185592680 @default.
- W4242800605 hasConcept C203014093 @default.
- W4242800605 hasConcept C2776151105 @default.
- W4242800605 hasConcept C2776165026 @default.
- W4242800605 hasConcept C2777103536 @default.
- W4242800605 hasConcept C2777622882 @default.
- W4242800605 hasConcept C2778784160 @default.
- W4242800605 hasConcept C2779385521 @default.
- W4242800605 hasConcept C2779525624 @default.
- W4242800605 hasConcept C2780795997 @default.
- W4242800605 hasConcept C519581460 @default.
- W4242800605 hasConcept C55493867 @default.
- W4242800605 hasConcept C86803240 @default.
- W4242800605 hasConceptScore W4242800605C159654299 @default.
- W4242800605 hasConceptScore W4242800605C163764329 @default.
- W4242800605 hasConceptScore W4242800605C178790620 @default.
- W4242800605 hasConceptScore W4242800605C181199279 @default.
- W4242800605 hasConceptScore W4242800605C185592680 @default.
- W4242800605 hasConceptScore W4242800605C203014093 @default.
- W4242800605 hasConceptScore W4242800605C2776151105 @default.
- W4242800605 hasConceptScore W4242800605C2776165026 @default.
- W4242800605 hasConceptScore W4242800605C2777103536 @default.
- W4242800605 hasConceptScore W4242800605C2777622882 @default.
- W4242800605 hasConceptScore W4242800605C2778784160 @default.
- W4242800605 hasConceptScore W4242800605C2779385521 @default.
- W4242800605 hasConceptScore W4242800605C2779525624 @default.
- W4242800605 hasConceptScore W4242800605C2780795997 @default.
- W4242800605 hasConceptScore W4242800605C519581460 @default.
- W4242800605 hasConceptScore W4242800605C55493867 @default.
- W4242800605 hasConceptScore W4242800605C86803240 @default.
- W4242800605 hasLocation W42428006051 @default.
- W4242800605 hasOpenAccess W4242800605 @default.
- W4242800605 hasPrimaryLocation W42428006051 @default.
- W4242800605 hasRelatedWork W1585029221 @default.
- W4242800605 hasRelatedWork W1725300350 @default.
- W4242800605 hasRelatedWork W1821918060 @default.
- W4242800605 hasRelatedWork W1983372621 @default.
- W4242800605 hasRelatedWork W1993089315 @default.
- W4242800605 hasRelatedWork W2014442715 @default.
- W4242800605 hasRelatedWork W2015290296 @default.
- W4242800605 hasRelatedWork W2041443867 @default.
- W4242800605 hasRelatedWork W2408313183 @default.
- W4242800605 hasRelatedWork W2799346595 @default.
- W4242800605 hasVolume "27" @default.
- W4242800605 isParatext "false" @default.
- W4242800605 isRetracted "false" @default.
- W4242800605 workType "article" @default.