FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242801075> ?p ?o ?g. }

• W4242801075 endingPage "881" @default.
• W4242801075 startingPage "877" @default.
• W4242801075 abstract "The major limitation of the usefulness of anthracyclines is the development of drug resistance. Most of the data related to anthracycline resistance has been obtained in experimental animal tumors or in cultured human cell lines. An important characteristic obtained in these models is the common finding of cross-resistance to a series of drugs structurally unrelated to the anthracyclines and with a mechanism of action which apparently differ from that of the anthracyclines. This phenomenon is defined as pleiotropic drug resistance or multidrug resistance (MDR). The cross-resistance demonstrated includes the vinca alkaloids, actinomycin D, colchicin and the epipodophyllotoxins. The best documented mechanism of resistance and mechanism of cross-resistance is decreased cellular drug accumulation. Several findings indicate that the underlying factor of the altered net uptake is an active drug extrusion in the resistant cells. Another important characteristic is the demonstration of a cell surface protein with a molecular weight of about 170,000 (GP 170). Genetic and biochemical evidence indicate that the MDR phenotype in both animal and human cells result from overexpression of the MDR-1 gene which encodes GP 170. Some findings suggest that GP 170 is a transport protein for cytotoxic hydrophobic drugs like the anthracyclines. Other findings suggest that this gene is also associated with intrinsic (natural) anthracycline resistance." @default.
• W4242801075 created "2022-05-12" @default.
• W4242801075 creator A5019807812 @default.
• W4242801075 creator A5052286535 @default.
• W4242801075 creator A5084893308 @default.
• W4242801075 date "1989-01-01" @default.
• W4242801075 modified "2023-10-14" @default.
• W4242801075 title "Anthracycline Resistance" @default.
• W4242801075 cites W1499694712 @default.
• W4242801075 cites W1532212172 @default.
• W4242801075 cites W1549117291 @default.
• W4242801075 cites W1572770561 @default.
• W4242801075 cites W1578072993 @default.
• W4242801075 cites W1872023806 @default.
• W4242801075 cites W1969795656 @default.
• W4242801075 cites W1971950332 @default.
• W4242801075 cites W1979783027 @default.
• W4242801075 cites W1986421470 @default.
• W4242801075 cites W1989012593 @default.
• W4242801075 cites W1996966081 @default.
• W4242801075 cites W1997241897 @default.
• W4242801075 cites W2005890366 @default.
• W4242801075 cites W2007931369 @default.
• W4242801075 cites W2012306261 @default.
• W4242801075 cites W2013540958 @default.
• W4242801075 cites W2014593961 @default.
• W4242801075 cites W2014811932 @default.
• W4242801075 cites W2016052720 @default.
• W4242801075 cites W2025811746 @default.
• W4242801075 cites W2029185839 @default.
• W4242801075 cites W2034031399 @default.
• W4242801075 cites W2038450925 @default.
• W4242801075 cites W2039358467 @default.
• W4242801075 cites W2049772927 @default.
• W4242801075 cites W2051201030 @default.
• W4242801075 cites W2058215061 @default.
• W4242801075 cites W2066920267 @default.
• W4242801075 cites W2075749214 @default.
• W4242801075 cites W2079032862 @default.
• W4242801075 cites W2108877577 @default.
• W4242801075 cites W2153712534 @default.
• W4242801075 cites W2257345960 @default.
• W4242801075 cites W2264155967 @default.
• W4242801075 cites W4231177125 @default.
• W4242801075 doi "https://doi.org/10.3109/02841868909092324" @default.
• W4242801075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2692650" @default.
• W4242801075 hasPublicationYear "1989" @default.
• W4242801075 type Work @default.
• W4242801075 citedByCount "9" @default.
• W4242801075 countsByYear W42428010752016 @default.
• W4242801075 countsByYear W42428010752022 @default.
• W4242801075 countsByYear W42428010752023 @default.
• W4242801075 crossrefType "journal-article" @default.
• W4242801075 hasAuthorship W4242801075A5019807812 @default.
• W4242801075 hasAuthorship W4242801075A5052286535 @default.
• W4242801075 hasAuthorship W4242801075A5084893308 @default.
• W4242801075 hasConcept C104317684 @default.
• W4242801075 hasConcept C111472728 @default.
• W4242801075 hasConcept C114851261 @default.
• W4242801075 hasConcept C121608353 @default.
• W4242801075 hasConcept C126322002 @default.
• W4242801075 hasConcept C127716648 @default.
• W4242801075 hasConcept C133936738 @default.
• W4242801075 hasConcept C138885662 @default.
• W4242801075 hasConcept C202751555 @default.
• W4242801075 hasConcept C2776120743 @default.
• W4242801075 hasConcept C2776802502 @default.
• W4242801075 hasConcept C2777022698 @default.
• W4242801075 hasConcept C2777096885 @default.
• W4242801075 hasConcept C2778080818 @default.
• W4242801075 hasConcept C2780035454 @default.
• W4242801075 hasConcept C502942594 @default.
• W4242801075 hasConcept C519063684 @default.
• W4242801075 hasConcept C530470458 @default.
• W4242801075 hasConcept C54355233 @default.
• W4242801075 hasConcept C71924100 @default.
• W4242801075 hasConcept C86803240 @default.
• W4242801075 hasConcept C89611455 @default.
• W4242801075 hasConcept C98274493 @default.
• W4242801075 hasConceptScore W4242801075C104317684 @default.
• W4242801075 hasConceptScore W4242801075C111472728 @default.
• W4242801075 hasConceptScore W4242801075C114851261 @default.
• W4242801075 hasConceptScore W4242801075C121608353 @default.
• W4242801075 hasConceptScore W4242801075C126322002 @default.
• W4242801075 hasConceptScore W4242801075C127716648 @default.
• W4242801075 hasConceptScore W4242801075C133936738 @default.
• W4242801075 hasConceptScore W4242801075C138885662 @default.
• W4242801075 hasConceptScore W4242801075C202751555 @default.
• W4242801075 hasConceptScore W4242801075C2776120743 @default.
• W4242801075 hasConceptScore W4242801075C2776802502 @default.
• W4242801075 hasConceptScore W4242801075C2777022698 @default.
• W4242801075 hasConceptScore W4242801075C2777096885 @default.
• W4242801075 hasConceptScore W4242801075C2778080818 @default.
• W4242801075 hasConceptScore W4242801075C2780035454 @default.
• W4242801075 hasConceptScore W4242801075C502942594 @default.
• W4242801075 hasConceptScore W4242801075C519063684 @default.
• W4242801075 hasConceptScore W4242801075C530470458 @default.
• W4242801075 hasConceptScore W4242801075C54355233 @default.

• next