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- W4242805655 abstract "A combination of sulfamethoxazole and trimethoprim (Bactrim) was given orally to 35 cancer patients with infections. Thirty-two patients did not respond to an initial antibiotic regimen that consisted primarily of carbenicillin disodium and an aminoglycoside. There were 18 single-organism, Gramnegative infections. The overall cure rate was 54%. The most common infection was pneumonia (47% responded to treatment). Eighty percent of the cases of septicemia were cured. The most common infecting organism was<i>Klebsiella pneumoniae</i>(45% with this infection responded). Eight cases of infection of unknown origin occurred (63% responded to treatment). Overall, 47% of the patients whose neutrophil count remained unchanged or decreased responded, while 61% of those whose neutrophil count remained unchanged or increased responded. There was no close correlation between the minimum inhibitory concentrations and the clinical responses. Sulfamethoxazole-trimethoprim orally is a well tolerated and effective form of antimicrobial therapy. (<i>JAMA</i>237:352-354, 1977)" @default.
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- W4242805655 date "1977-01-24" @default.
- W4242805655 modified "2023-10-09" @default.
- W4242805655 title "Sulfamethoxazole-trimethoprim for infections in cancer patients" @default.
- W4242805655 doi "https://doi.org/10.1001/jama.237.4.352" @default.
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