FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242807478> ?p ?o ?g. }

• W4242807478 endingPage "67" @default.
• W4242807478 startingPage "57" @default.
• W4242807478 abstract "Endometriosis is a gynecological condition associated with infertility. We have previously demonstrated dysregulation of several molecular markers of uterine receptivity in a baboon model of induced endometriosis. Specifically, reduced levels of endometrial progesterone receptor (PR) and progesterone (P)-regulated genes, HOXA10 and FKBP52 were observed during the window of uterine receptivity in baboons with endometriosis, suggesting that this disease results in the development of an endometrial P resistance. In this study calcitonin (CALC) and CALC-modulated proteins, E-cadherin (E-Cad) and tissue Transglutaminase (tTgase-2) were evaluated in the eutopic endometrium of endometriotic animals throughout disease progression. Endometriosis was induced in normal cycling baboons by intraperitoneal inoculation of menstrual endometrium. Eutopic and ectopic endometrium was harvested consecutively from each animal at 1, 6 and 15 months of disease, during the window of receptivity. Control eutopic endometrium was similarly harvested from disease free baboons. Immunohistochemistry for CALC, E-cad and tTgase-2, was performed on formalin fixed tissues embedded in paraffin following antigen retrieval. CALC immunostaining was localized in the glandular and luminal epithelium as well as in the uterine stromal cells in disease free eutopic endometrium. However, in the eutopic endometrium from endometriotic baboons there was a reduction of CALC in the luminal and glandular epithelium as well as a reduction in the stromal cells. In the ectopic endometrium there was no immunostaining for the CALC protein. E-cad protein was immunolocalized primarily to the glandular epithelium of both control and endometriotic eutopic endometria. However, E-cad immunostaining was markedly increased in endometria of baboons with disease. The immunostaining was weak for E-Cad in the ectopic endometrial lesions regardless of color or location in the peritoneum. Strong immunostaining for tTgase-2 was observed in the stroma in disease free controls. Endometria from animals with endometriosis demonstrated a progressive loss of tTgase-2 immunostaining in the stroma throughout the time course of disease. There was strong immunostaining in the stroma of the ectopic endometrial collected throughout disease progression. The maintained levels of E-cad and reduced levels of tTgase-2 correlate with the reduction of CALC in eutopic endometria of baboons with endometriosis. These data suggest that the reduced fecundity associated with endometriosis is mediated, in part, by a progesterone resistance that affects not only genes directly regulated by progesterone, but those that are down-stream targets of progesterone regulated genes." @default.
• W4242807478 created "2022-05-12" @default.
• W4242807478 creator A5022400005 @default.
• W4242807478 creator A5040987146 @default.
• W4242807478 creator A5051414712 @default.
• W4242807478 creator A5059693281 @default.
• W4242807478 creator A5085937402 @default.
• W4242807478 date "2009-01-01" @default.
• W4242807478 modified "2023-10-17" @default.
• W4242807478 title "Alterations in the Calcitonin and Calcitonin Modulated Proteins, E-Cadherin and the Enzyme Tissue Transglutaminase II during the Window of Implantation in a Baboon Model of Endometriosis" @default.
• W4242807478 cites W1567400069 @default.
• W4242807478 cites W1596773677 @default.
• W4242807478 cites W1984332162 @default.
• W4242807478 cites W1989066573 @default.
• W4242807478 cites W1992005694 @default.
• W4242807478 cites W1993356718 @default.
• W4242807478 cites W1996175040 @default.
• W4242807478 cites W2000185144 @default.
• W4242807478 cites W2003134832 @default.
• W4242807478 cites W2010311608 @default.
• W4242807478 cites W2011708238 @default.
• W4242807478 cites W2013922909 @default.
• W4242807478 cites W2014683547 @default.
• W4242807478 cites W2019014038 @default.
• W4242807478 cites W2021270230 @default.
• W4242807478 cites W2026948342 @default.
• W4242807478 cites W2033853439 @default.
• W4242807478 cites W2035323213 @default.
• W4242807478 cites W2044151925 @default.
• W4242807478 cites W2052734212 @default.
• W4242807478 cites W2053756955 @default.
• W4242807478 cites W2055430160 @default.
• W4242807478 cites W2057372634 @default.
• W4242807478 cites W2059586053 @default.
• W4242807478 cites W2061413318 @default.
• W4242807478 cites W2067403820 @default.
• W4242807478 cites W2067514944 @default.
• W4242807478 cites W2068819752 @default.
• W4242807478 cites W2069691297 @default.
• W4242807478 cites W2084012273 @default.
• W4242807478 cites W2089239796 @default.
• W4242807478 cites W2089714150 @default.
• W4242807478 cites W2091998704 @default.
• W4242807478 cites W2092340366 @default.
• W4242807478 cites W2097839537 @default.
• W4242807478 cites W2099271665 @default.
• W4242807478 cites W2100567214 @default.
• W4242807478 cites W2103654313 @default.
• W4242807478 cites W2107976817 @default.
• W4242807478 cites W2108118435 @default.
• W4242807478 cites W2108342056 @default.
• W4242807478 cites W2108360007 @default.
• W4242807478 cites W2109004108 @default.
• W4242807478 cites W2109016302 @default.
• W4242807478 cites W2113177481 @default.
• W4242807478 cites W2115337375 @default.
• W4242807478 cites W2123147801 @default.
• W4242807478 cites W2126377736 @default.
• W4242807478 cites W2130585082 @default.
• W4242807478 cites W2133298416 @default.
• W4242807478 cites W2137799669 @default.
• W4242807478 cites W2140595625 @default.
• W4242807478 cites W2143049848 @default.
• W4242807478 cites W2153988048 @default.
• W4242807478 cites W2157560598 @default.
• W4242807478 cites W2158289124 @default.
• W4242807478 cites W2164096066 @default.
• W4242807478 cites W2203749559 @default.
• W4242807478 doi "https://doi.org/10.1177/228402650900100109" @default.
• W4242807478 hasPublicationYear "2009" @default.
• W4242807478 type Work @default.
• W4242807478 citedByCount "4" @default.
• W4242807478 countsByYear W42428074782012 @default.
• W4242807478 crossrefType "journal-article" @default.
• W4242807478 hasAuthorship W4242807478A5022400005 @default.
• W4242807478 hasAuthorship W4242807478A5040987146 @default.
• W4242807478 hasAuthorship W4242807478A5051414712 @default.
• W4242807478 hasAuthorship W4242807478A5059693281 @default.
• W4242807478 hasAuthorship W4242807478A5085937402 @default.
• W4242807478 hasConcept C126322002 @default.
• W4242807478 hasConcept C134018914 @default.
• W4242807478 hasConcept C142724271 @default.
• W4242807478 hasConcept C16930146 @default.
• W4242807478 hasConcept C204232928 @default.
• W4242807478 hasConcept C2779522080 @default.
• W4242807478 hasConcept C2779594886 @default.
• W4242807478 hasConcept C2779742232 @default.
• W4242807478 hasConcept C4224716 @default.
• W4242807478 hasConcept C71924100 @default.
• W4242807478 hasConceptScore W4242807478C126322002 @default.
• W4242807478 hasConceptScore W4242807478C134018914 @default.
• W4242807478 hasConceptScore W4242807478C142724271 @default.
• W4242807478 hasConceptScore W4242807478C16930146 @default.
• W4242807478 hasConceptScore W4242807478C204232928 @default.
• W4242807478 hasConceptScore W4242807478C2779522080 @default.
• W4242807478 hasConceptScore W4242807478C2779594886 @default.
• W4242807478 hasConceptScore W4242807478C2779742232 @default.
• W4242807478 hasConceptScore W4242807478C4224716 @default.

• next