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- W4242829191 abstract "Abstract1. The malate/2-oxoglutarate antiporter activity of kidney cortex mitochondria from acidotic rats was higher than in mitochondria from control animals as measured by the rate of swelling of these mitochondria in isoosmotic solutions of ammonium 2-oxoglutarate. 2. This finding was confirmed by inhibitor-stop experiments in which [14C]2-oxoglutarate influx into malate-loaded mitochondria was measured at 0°C using phenylsuccinate as an inhibitor. 3. In mitochondria from control rats a transport rate of 13 ± 6 nmolmin-1 mg protein-1 and a Km for external 2-oxoglutarate of 37 ± 6 μM were found. 4. After 7 days of NH4Cl-induced acidosis there was a significant 70% increase in transporter activity with no change in Km. The relationship of these changes to glutamine metabolism is discussed." @default.
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- W4242829191 date "1980-01-01" @default.
- W4242829191 modified "2023-10-14" @default.
- W4242829191 title "THE MALATE/2-OXOGLUTARATE TRANSPORTER IN MITOCHONDRIA FROM RAT KIDNEY CORTEX: INCREASED ACTIVITY IN METABOLIC ACIDOSIS" @default.
- W4242829191 doi "https://doi.org/10.1016/b978-0-08-025517-0.50031-x" @default.
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