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- W4242849810 abstract "Background. Dendritic pathology and decrease of dendritic spine density is a prominent phenomena in early cases of Alzheimer's disease, which correlates significantly with the progressive decline of the mental faculties. In previous studies we have described the pathological alterations of the dendrites and the dendritic spines in the prefrontal area of the cortex and the cerebellum. Methods In this study we attempted to describe the morphological alterations of the dendrites and the dendritic spines, quantifying them in the acoustic and the visual cortices of eleven cases of Alzheimer's disease, applying Golgi silver imregnation technique and electron microscopy. Results. The light microscope revealed the dendritic alterations and the morpholological and morphometric changes of dendritic spines in neurons of the primary acoustic cortex and the visual cortex (V1 or 17 area). In addition, describing also the ultrastructural changes of the mitochondria in the dendritic profiles and the dendritic spines we noticed that mitochondrial pathology correlates substantially with the dystrophic dendrites, the loss of dendritic branches and the pathological alteration of the dendritic spines. Conclusion. We would hypothesize that mitochondrial alterations may play a very important role in dendritic degeneration and the loss of dendritic spines and we should have thought that therapeutic strategies protecting the mitochondria may be beneficial in Alzheimer's disease." @default.
- W4242849810 created "2022-05-12" @default.
- W4242849810 creator A5070850785 @default.
- W4242849810 date "2009-07-01" @default.
- W4242849810 modified "2023-09-27" @default.
- W4242849810 title "P2-128: DeNdritic pathology in Alzheimer's disease" @default.
- W4242849810 doi "https://doi.org/10.1016/j.jalz.2009.04.439" @default.
- W4242849810 hasPublicationYear "2009" @default.
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