Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242864978> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W4242864978 endingPage "246" @default.
- W4242864978 startingPage "246" @default.
- W4242864978 abstract "In vitro model of the human cardiac tissues generated from human induced pluripotent stem cells (hiPSCs) could facilitate drug discovery and patient-specific studies of physiology and disease. However, the immature state of hiPSC-derived cardiomyocytes (hiPSC-CMs) compared to adult myocardium is a key defect that must be overcome to enable the potential applications of hiPSC-CMs in drug testing. For this purpose, we developed a heart-on-a-chip device that contains microfluidic channels for long-term dynamic culture of cells, platinum wire electrodes for electrical stimulation of hiPSC-CMs, and gold electrode arrays as acquisition electrodes for real-time recording electrophysiological signals of cardiac tissues. Human iPSC-CMs cultured on biocompatible hydrogels in the chip chamber can be electrically stimulated to prompt the maturation of cardiomyocytes (CMs) and generate functional cardiac tissues. Drug tests were performed with calcium transient measurements to evaluate drug responsiveness of electrical stimulated and unstimulated cardiac tissues. The results show that only the electrical-stimulated cardiac tissues respond correctly to drug treatment of verapamil and isoprenaline, indicating the reliability of this engineered cardiac tissues for drug testing. The above integrated heart-on-a-chip device provides a promising platform for drug efficacy testing and cardiactoxicity." @default.
- W4242864978 created "2022-05-12" @default.
- W4242864978 date "1971-10-01" @default.
- W4242864978 modified "2023-09-25" @default.
- W4242864978 title "Velocity dispersion of waves propagating along the edge of a plate" @default.
- W4242864978 doi "https://doi.org/10.1016/0041-624x(71)90432-x" @default.
- W4242864978 hasPublicationYear "1971" @default.
- W4242864978 type Work @default.
- W4242864978 citedByCount "0" @default.
- W4242864978 crossrefType "journal-article" @default.
- W4242864978 hasConcept C104317684 @default.
- W4242864978 hasConcept C107459253 @default.
- W4242864978 hasConcept C126322002 @default.
- W4242864978 hasConcept C136229726 @default.
- W4242864978 hasConcept C145103041 @default.
- W4242864978 hasConcept C185263204 @default.
- W4242864978 hasConcept C185592680 @default.
- W4242864978 hasConcept C192562407 @default.
- W4242864978 hasConcept C55493867 @default.
- W4242864978 hasConcept C71924100 @default.
- W4242864978 hasConceptScore W4242864978C104317684 @default.
- W4242864978 hasConceptScore W4242864978C107459253 @default.
- W4242864978 hasConceptScore W4242864978C126322002 @default.
- W4242864978 hasConceptScore W4242864978C136229726 @default.
- W4242864978 hasConceptScore W4242864978C145103041 @default.
- W4242864978 hasConceptScore W4242864978C185263204 @default.
- W4242864978 hasConceptScore W4242864978C185592680 @default.
- W4242864978 hasConceptScore W4242864978C192562407 @default.
- W4242864978 hasConceptScore W4242864978C55493867 @default.
- W4242864978 hasConceptScore W4242864978C71924100 @default.
- W4242864978 hasIssue "4" @default.
- W4242864978 hasLocation W42428649781 @default.
- W4242864978 hasOpenAccess W4242864978 @default.
- W4242864978 hasPrimaryLocation W42428649781 @default.
- W4242864978 hasRelatedWork W1448088071 @default.
- W4242864978 hasRelatedWork W2035312069 @default.
- W4242864978 hasRelatedWork W2053798951 @default.
- W4242864978 hasRelatedWork W2196158458 @default.
- W4242864978 hasRelatedWork W2593942001 @default.
- W4242864978 hasRelatedWork W2891816541 @default.
- W4242864978 hasRelatedWork W2899084033 @default.
- W4242864978 hasRelatedWork W3113787517 @default.
- W4242864978 hasRelatedWork W3184368404 @default.
- W4242864978 hasRelatedWork W3209815105 @default.
- W4242864978 hasVolume "9" @default.
- W4242864978 isParatext "false" @default.
- W4242864978 isRetracted "false" @default.
- W4242864978 workType "article" @default.