Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242885775> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4242885775 abstract "Abstract Nowadays despite conventional methods in colon cancer treatment, targeting vital molecular pathways and induction of various forms of cell death by safe probiotic components like exopolysaccharides (EPSs) are of great importance and are considered as potential therapeutic agents. This study aimed to investigate the inhibitory effect of the EPS of L. paracasei on different colon cancer cell lines (SW-480, HT-29, and HCT-116). For this purpose, several cellular and molecular experiments including MTS assay, DAPI staining, Annexin V/PI assay, quantitative real-time PCR (qPCR) and some important ferroptosis-related assays were performed. Based on the findings, L. paracasei EPS can induce apoptosis confirmed by all apoptosis-related assays and could not act through ferroptosis pathways. L. paracasei EPS could hinder the Akt1, mTOR, and Jak-1 mRNAs, and induces apoptosis through down-regulation of the anti-apoptotic gene (Bcl-2), up-regulation of pro-apoptotic genes (BAX, caspase-3, 8). The exploited EPS of an indigenous probiotic strain with anticancer potential with low/insignificant cytotoxicity to normal cells is proposed for future applications in molecular-targeted therapy of colon cancer treatment. Furthermore, in vivo and clinical trials should be performed to evaluate the applicability of this component besides conventional methods to increase the survival rate of colon cancer patients." @default.
- W4242885775 created "2022-05-12" @default.
- W4242885775 creator A5005474843 @default.
- W4242885775 creator A5010420618 @default.
- W4242885775 creator A5044885273 @default.
- W4242885775 creator A5082148193 @default.
- W4242885775 creator A5083342809 @default.
- W4242885775 date "2020-03-12" @default.
- W4242885775 modified "2023-10-16" @default.
- W4242885775 title "Prophylactic role of Lactobacillus Paracasei exopolysaccharides on colon cancer cells through apoptosis not ferroptosis" @default.
- W4242885775 doi "https://doi.org/10.21203/rs.3.rs-16965/v1" @default.
- W4242885775 hasPublicationYear "2020" @default.
- W4242885775 type Work @default.
- W4242885775 citedByCount "1" @default.
- W4242885775 crossrefType "posted-content" @default.
- W4242885775 hasAuthorship W4242885775A5005474843 @default.
- W4242885775 hasAuthorship W4242885775A5010420618 @default.
- W4242885775 hasAuthorship W4242885775A5044885273 @default.
- W4242885775 hasAuthorship W4242885775A5082148193 @default.
- W4242885775 hasAuthorship W4242885775A5083342809 @default.
- W4242885775 hasBestOaLocation W42428857751 @default.
- W4242885775 hasConcept C109316439 @default.
- W4242885775 hasConcept C121608353 @default.
- W4242885775 hasConcept C190283241 @default.
- W4242885775 hasConcept C202751555 @default.
- W4242885775 hasConcept C2777527632 @default.
- W4242885775 hasConcept C2779433226 @default.
- W4242885775 hasConcept C2780255968 @default.
- W4242885775 hasConcept C2780670749 @default.
- W4242885775 hasConcept C31573885 @default.
- W4242885775 hasConcept C502942594 @default.
- W4242885775 hasConcept C523546767 @default.
- W4242885775 hasConcept C526805850 @default.
- W4242885775 hasConcept C54355233 @default.
- W4242885775 hasConcept C55493867 @default.
- W4242885775 hasConcept C86803240 @default.
- W4242885775 hasConcept C88634738 @default.
- W4242885775 hasConceptScore W4242885775C109316439 @default.
- W4242885775 hasConceptScore W4242885775C121608353 @default.
- W4242885775 hasConceptScore W4242885775C190283241 @default.
- W4242885775 hasConceptScore W4242885775C202751555 @default.
- W4242885775 hasConceptScore W4242885775C2777527632 @default.
- W4242885775 hasConceptScore W4242885775C2779433226 @default.
- W4242885775 hasConceptScore W4242885775C2780255968 @default.
- W4242885775 hasConceptScore W4242885775C2780670749 @default.
- W4242885775 hasConceptScore W4242885775C31573885 @default.
- W4242885775 hasConceptScore W4242885775C502942594 @default.
- W4242885775 hasConceptScore W4242885775C523546767 @default.
- W4242885775 hasConceptScore W4242885775C526805850 @default.
- W4242885775 hasConceptScore W4242885775C54355233 @default.
- W4242885775 hasConceptScore W4242885775C55493867 @default.
- W4242885775 hasConceptScore W4242885775C86803240 @default.
- W4242885775 hasConceptScore W4242885775C88634738 @default.
- W4242885775 hasLocation W42428857751 @default.
- W4242885775 hasOpenAccess W4242885775 @default.
- W4242885775 hasPrimaryLocation W42428857751 @default.
- W4242885775 hasRelatedWork W13961559 @default.
- W4242885775 hasRelatedWork W17296605 @default.
- W4242885775 hasRelatedWork W18188179 @default.
- W4242885775 hasRelatedWork W1994912 @default.
- W4242885775 hasRelatedWork W20825810 @default.
- W4242885775 hasRelatedWork W2919013 @default.
- W4242885775 hasRelatedWork W29692181 @default.
- W4242885775 hasRelatedWork W6582217 @default.
- W4242885775 hasRelatedWork W9640825 @default.
- W4242885775 hasRelatedWork W19522458 @default.
- W4242885775 isParatext "false" @default.
- W4242885775 isRetracted "false" @default.
- W4242885775 workType "article" @default.