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- W4242911221 abstract "We have generated and analyzed by functional assays mutations of the chicken erythroid transcription factor GATA-1. The cGATA-1 protein contains two related finger domains highly conserved across species and characteristic of the family of GATA-binding factors. We find that mutations in the C-terminal finger or adjacent basic region abolish sequence-specific DNA binding, confirming that this region constitutes a novel DNA-binding domain sufficient to recognize the consensus WGATAR motif. At least three separate regions outside of this finger II domain contribute in a cooperative manner to the trans-activation potential of the protein. As expected from previous results analyzing the mouse homolog, we find that the N-terminal finger plays a role in DNA binding by affecting the stability of the DNA-protein complex. In addition, we find mutations of finger I subtly altered in DNA-binding function which greatly diminish trans-activation. Our results support the notion that the GATA-1 protein must be positioned precisely on the GATA cis element to enable the activation of target genes." @default.
- W4242911221 created "2022-05-12" @default.
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- W4242911221 date "1992-10-01" @default.
- W4242911221 modified "2023-10-17" @default.
- W4242911221 title "Distinct roles for the two cGATA-1 finger domains." @default.
- W4242911221 doi "https://doi.org/10.1128/mcb.12.10.4562" @default.
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