Matches in SemOpenAlex for { <https://semopenalex.org/work/W4242927800> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4242927800 abstract "Abstract Background. Idiopathic Parkinson’s disease (iPD) and Type 2 Diabetes Mellitus (T2DM) are chronic, degenerative, multisystemic and age-related diseases, with eventual epidemiological co-morbidity and potential overlap in molecular basis. This study aims to explore if metabolic and mitochondrial alterations underlie the suggested epidemiologic and clinical co-morbidity at molecular level. Methods. To evaluate the adaptation of iPD to a simulated pre-diabetogenic state, we exposed primary cultured fibroblasts from iPD patients and controls to standard (5mM) and high (25mM) glucose concentrations to further characterize metabolic and mitochondrial resilience. Results. iPD fibroblasts showed increased levels of organic and amino acid levels related to mitochondrial metabolism with respect to controls, and these differences were enhanced in high glucose conditions (citric, suberic and sebacic acids levels increased, as well as alanine, glutamate, aspartate, arginine and ornithine amino acids; p-values between 0.001 and p=0.05). The accumulation of metabolites in iPD fibroblasts was associated (and probably due) to the concomitant mitochondrial dysfunction observed at enzymatic, oxidative, respiratory and morphologic level. Metabolic and mitochondrial plasticity of controls was not observed in iPD fibroblasts, that were unable to adapt to different glucose conditions. Impaired metabolism and mitochondrial activity in iPD may limit energy supply for cell survival. Moreover, deficient plasticity to adapt to disrupted glucose balance characteristic of T2DM may underlay the comorbidity between both diseases. Conclusions: Fibroblasts form iPD patients showed mitochondrial impairment resulting in the accumulation of organic and amino acids related to mitochondrial metabolism, especially when exposed to high glucose condition. Mitochondrial and metabolic defects down warding cell plasticity to adapt to changing glucose bioavailability may explain the comorbidity between iPD and T2DM." @default.
- W4242927800 created "2022-05-12" @default.
- W4242927800 creator A5012965114 @default.
- W4242927800 creator A5014092852 @default.
- W4242927800 creator A5014671548 @default.
- W4242927800 creator A5021343613 @default.
- W4242927800 creator A5025718532 @default.
- W4242927800 creator A5031061515 @default.
- W4242927800 creator A5034622775 @default.
- W4242927800 creator A5039879107 @default.
- W4242927800 creator A5041792199 @default.
- W4242927800 creator A5048811883 @default.
- W4242927800 creator A5049502478 @default.
- W4242927800 creator A5049787142 @default.
- W4242927800 creator A5055416799 @default.
- W4242927800 creator A5061421108 @default.
- W4242927800 creator A5063250119 @default.
- W4242927800 creator A5077658775 @default.
- W4242927800 creator A5078689202 @default.
- W4242927800 creator A5080875810 @default.
- W4242927800 creator A5080906950 @default.
- W4242927800 creator A5081123756 @default.
- W4242927800 creator A5086187645 @default.
- W4242927800 creator A5087181705 @default.
- W4242927800 creator A5089690007 @default.
- W4242927800 date "2020-08-24" @default.
- W4242927800 modified "2023-10-18" @default.
- W4242927800 title "Disrupted Mitochondrial and Metabolic Plasticity Underlie Comorbidity Between Age-related and Degenerative Disorders as Parkinson Disease and Type 2 Diabetes Mellitus" @default.
- W4242927800 doi "https://doi.org/10.21203/rs.3.rs-58082/v1" @default.
- W4242927800 hasPublicationYear "2020" @default.
- W4242927800 type Work @default.
- W4242927800 citedByCount "0" @default.
- W4242927800 crossrefType "posted-content" @default.
- W4242927800 hasAuthorship W4242927800A5012965114 @default.
- W4242927800 hasAuthorship W4242927800A5014092852 @default.
- W4242927800 hasAuthorship W4242927800A5014671548 @default.
- W4242927800 hasAuthorship W4242927800A5021343613 @default.
- W4242927800 hasAuthorship W4242927800A5025718532 @default.
- W4242927800 hasAuthorship W4242927800A5031061515 @default.
- W4242927800 hasAuthorship W4242927800A5034622775 @default.
- W4242927800 hasAuthorship W4242927800A5039879107 @default.
- W4242927800 hasAuthorship W4242927800A5041792199 @default.
- W4242927800 hasAuthorship W4242927800A5048811883 @default.
- W4242927800 hasAuthorship W4242927800A5049502478 @default.
- W4242927800 hasAuthorship W4242927800A5049787142 @default.
- W4242927800 hasAuthorship W4242927800A5055416799 @default.
- W4242927800 hasAuthorship W4242927800A5061421108 @default.
- W4242927800 hasAuthorship W4242927800A5063250119 @default.
- W4242927800 hasAuthorship W4242927800A5077658775 @default.
- W4242927800 hasAuthorship W4242927800A5078689202 @default.
- W4242927800 hasAuthorship W4242927800A5080875810 @default.
- W4242927800 hasAuthorship W4242927800A5080906950 @default.
- W4242927800 hasAuthorship W4242927800A5081123756 @default.
- W4242927800 hasAuthorship W4242927800A5086187645 @default.
- W4242927800 hasAuthorship W4242927800A5087181705 @default.
- W4242927800 hasAuthorship W4242927800A5089690007 @default.
- W4242927800 hasBestOaLocation W42429278001 @default.
- W4242927800 hasConcept C126322002 @default.
- W4242927800 hasConcept C134018914 @default.
- W4242927800 hasConcept C17093226 @default.
- W4242927800 hasConcept C2776151105 @default.
- W4242927800 hasConcept C2777180221 @default.
- W4242927800 hasConcept C2777735490 @default.
- W4242927800 hasConcept C2779159551 @default.
- W4242927800 hasConcept C28859421 @default.
- W4242927800 hasConcept C55493867 @default.
- W4242927800 hasConcept C555293320 @default.
- W4242927800 hasConcept C71924100 @default.
- W4242927800 hasConcept C86803240 @default.
- W4242927800 hasConceptScore W4242927800C126322002 @default.
- W4242927800 hasConceptScore W4242927800C134018914 @default.
- W4242927800 hasConceptScore W4242927800C17093226 @default.
- W4242927800 hasConceptScore W4242927800C2776151105 @default.
- W4242927800 hasConceptScore W4242927800C2777180221 @default.
- W4242927800 hasConceptScore W4242927800C2777735490 @default.
- W4242927800 hasConceptScore W4242927800C2779159551 @default.
- W4242927800 hasConceptScore W4242927800C28859421 @default.
- W4242927800 hasConceptScore W4242927800C55493867 @default.
- W4242927800 hasConceptScore W4242927800C555293320 @default.
- W4242927800 hasConceptScore W4242927800C71924100 @default.
- W4242927800 hasConceptScore W4242927800C86803240 @default.
- W4242927800 hasLocation W42429278001 @default.
- W4242927800 hasLocation W42429278002 @default.
- W4242927800 hasLocation W42429278003 @default.
- W4242927800 hasOpenAccess W4242927800 @default.
- W4242927800 hasPrimaryLocation W42429278001 @default.
- W4242927800 hasRelatedWork W1998542420 @default.
- W4242927800 hasRelatedWork W2002888717 @default.
- W4242927800 hasRelatedWork W2003150205 @default.
- W4242927800 hasRelatedWork W2003811568 @default.
- W4242927800 hasRelatedWork W2054690921 @default.
- W4242927800 hasRelatedWork W2063441939 @default.
- W4242927800 hasRelatedWork W2068892774 @default.
- W4242927800 hasRelatedWork W2082995727 @default.
- W4242927800 hasRelatedWork W2127396703 @default.
- W4242927800 hasRelatedWork W2153591790 @default.
- W4242927800 isParatext "false" @default.
- W4242927800 isRetracted "false" @default.
- W4242927800 workType "article" @default.