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- W4242956398 abstract "Regulation of pancreatic protein synthesis and growth allows the exocrine pancreas to provide an adequate supply of digestive enzymes for nutrient assimilation. Long-term dietary regulation occurs at the transcriptional level. For example, a high carbohydrate diet can lead to enhanced amylase gene transcription and protein synthesis. Short-term regulation to increase digestive enzyme synthesis in response to a meal occurs by translational regulation. This is mediated primarily by the Akt/mTORC1 pathway and is initiated by insulin, amino acids, cholecystokinin (CCK), and acetylcholine. When the need for digestive enzymes is great, the pancreas in many species shows adaptive growth in situations such as pregnancy and lactation that are accompanied by hyperphagia. Pancreatic growth involves stimulation primarily by CCK of the calcineurin–NFAT, mTORC1, and ERK pathways and can result in both an increase in cell size (hypertrophy) or division of existing mature acinar cells (hyperplasia). Hypertrophy is mediated primarily by the mTORC1 pathway whereas hyperplasia requires all three pathways to activate the cell cycle in acinar cells. Following damage that occurs with pancreatitis, regenerative growth occurs in a sequence composed of dedifferentiation, proliferation, and redifferentiation." @default.
- W4242956398 created "2022-05-12" @default.
- W4242956398 creator A5038874883 @default.
- W4242956398 creator A5053609858 @default.
- W4242956398 date "2018-02-12" @default.
- W4242956398 modified "2023-10-14" @default.
- W4242956398 title "Regulation of Pancreatic Protein Synthesis and Growth" @default.
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- W4242956398 doi "https://doi.org/10.1002/9781119188421.ch9" @default.
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