FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243010129> ?p ?o ?g. }

• W4243010129 abstract "Background Clinical trials have proven that surfactant therapy is effective in improving the immediate need for respiratory support and the clinical outcome of premature newborns (Soll 1992, Jobe 1993). Trials have studied a wide variety of surfactant preparations used either to prevent (prophylactic or delivery room administration) or treat (selective or rescue administration) respiratory distress syndrome. Using either treatment strategy, significant reductions in the incidence of pneumothorax, as well as significant improvement in survival, have been noted. It is unclear if there is an advantage to choosing either the prophylactic or selective approach to treatment Objectives To compare the effect of prophylactic surfactant administration to surfactant treatment of established respiratory distress syndrome in premature infants. Search methods Searches were made of the Oxford Database of Perinatal Trials, Medline (MeSH terms: pulmonary surfactant; limits: age groups, newborn infants; publication type, clinical trials), previous reviews including cross‐references, abstracts, conference and symposia proceedings, expert informants, and journal handsearching in the English language. Selection criteria Randomized controlled trials that compared the effects of prophylactic surfactant administration to surfactant treatment of established respiratory distress syndrome in premature infants were included in the analysis. Data collection and analysis Data regarding clinical outcomes including the incidence of pneumothorax, pulmonary interstitial emphysema, patent ductus arteriosus, necrotizing enterocolitis, intraventricular hemorrhage (any grade and severe intraventricular hemorrhage), bronchopulmonary dysplasia, mortality, bronchopulmonary dysplasia or death, and retinopathy of prematurity were excerpted from the reports of the clinical trials by the reviewers. Data analysis was done in accordance with the standards of the Cochrane Neonatal Review Group. Main results Eight studies were identified that met inclusion criteria. The majority of included studies noted an initial improvement in the respiratory status and a decrease in the incidence of respiratory distress syndrome in infants who received prophylactic surfactant. The meta‐analysis supports a decrease in the incidence of pneumothorax, a decrease in the incidence of pulmonary interstitial emphysema, a decrease in the incidence of mortality and a decrease in the incidence of bronchopulmonary dysplasia or death associated with prophylactic administration of surfactant. No significant untoward effects of prophylactic surfactant administration are noted. In a secondary analysis of infants less than 30 weeks gestation, the meta‐analysis suggests a significant decrease in the risk of neonatal mortality and the risk of mortality or bronchopulmonary dysplasia. Authors' conclusions Prophylactic surfactant administration to infants judged to be at risk of developing respiratory distress syndrome (infants less than 30‐32 weeks gestation), compared to selective use of surfactant in infants with established RDS, has been demonstrated to improve clinical outcome. Infants who receive prophylactic surfactant have a decreased risk of pneumothorax, a decreased risk of pulmonary interstitial emphysema and a decreased risk of mortality. However, it remains unclear exactly which criteria should be used to judge at risk infants who would require prophylactic surfactant administration." @default.
• W4243010129 created "2022-05-12" @default.
• W4243010129 creator A5036299725 @default.
• W4243010129 creator A5090204853 @default.
• W4243010129 date "2001-04-23" @default.
• W4243010129 modified "2023-10-06" @default.
• W4243010129 title "Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants" @default.
• W4243010129 cites W1518678424 @default.
• W4243010129 cites W1724529511 @default.
• W4243010129 cites W1969069646 @default.
• W4243010129 cites W1979301478 @default.
• W4243010129 cites W1989132333 @default.
• W4243010129 cites W2000480240 @default.
• W4243010129 cites W2015044946 @default.
• W4243010129 cites W2032515502 @default.
• W4243010129 cites W2034818022 @default.
• W4243010129 cites W2037229349 @default.
• W4243010129 cites W2046766740 @default.
• W4243010129 cites W2075132426 @default.
• W4243010129 cites W2079572716 @default.
• W4243010129 cites W2081757454 @default.
• W4243010129 cites W2153001272 @default.
• W4243010129 cites W2160226288 @default.
• W4243010129 cites W2335075431 @default.
• W4243010129 cites W4233584275 @default.
• W4243010129 cites W4296588342 @default.
• W4243010129 doi "https://doi.org/10.1002/14651858.cd000510" @default.
• W4243010129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10796379" @default.
• W4243010129 hasPublicationYear "2001" @default.
• W4243010129 type Work @default.
• W4243010129 citedByCount "137" @default.
• W4243010129 countsByYear W42430101292012 @default.
• W4243010129 countsByYear W42430101292013 @default.
• W4243010129 countsByYear W42430101292014 @default.
• W4243010129 countsByYear W42430101292015 @default.
• W4243010129 countsByYear W42430101292016 @default.
• W4243010129 countsByYear W42430101292017 @default.
• W4243010129 countsByYear W42430101292018 @default.
• W4243010129 countsByYear W42430101292019 @default.
• W4243010129 countsByYear W42430101292020 @default.
• W4243010129 countsByYear W42430101292021 @default.
• W4243010129 countsByYear W42430101292022 @default.
• W4243010129 crossrefType "reference-entry" @default.
• W4243010129 hasAuthorship W4243010129A5036299725 @default.
• W4243010129 hasAuthorship W4243010129A5090204853 @default.
• W4243010129 hasConcept C126322002 @default.
• W4243010129 hasConcept C141071460 @default.
• W4243010129 hasConcept C141983124 @default.
• W4243010129 hasConcept C168563851 @default.
• W4243010129 hasConcept C177713679 @default.
• W4243010129 hasConcept C187212893 @default.
• W4243010129 hasConcept C2777050789 @default.
• W4243010129 hasConcept C2777714996 @default.
• W4243010129 hasConcept C2778329176 @default.
• W4243010129 hasConcept C2778376644 @default.
• W4243010129 hasConcept C2778721537 @default.
• W4243010129 hasConcept C2779234561 @default.
• W4243010129 hasConcept C2779252433 @default.
• W4243010129 hasConcept C2779303187 @default.
• W4243010129 hasConcept C2779918416 @default.
• W4243010129 hasConcept C535046627 @default.
• W4243010129 hasConcept C54355233 @default.
• W4243010129 hasConcept C71924100 @default.
• W4243010129 hasConcept C86803240 @default.
• W4243010129 hasConceptScore W4243010129C126322002 @default.
• W4243010129 hasConceptScore W4243010129C141071460 @default.
• W4243010129 hasConceptScore W4243010129C141983124 @default.
• W4243010129 hasConceptScore W4243010129C168563851 @default.
• W4243010129 hasConceptScore W4243010129C177713679 @default.
• W4243010129 hasConceptScore W4243010129C187212893 @default.
• W4243010129 hasConceptScore W4243010129C2777050789 @default.
• W4243010129 hasConceptScore W4243010129C2777714996 @default.
• W4243010129 hasConceptScore W4243010129C2778329176 @default.
• W4243010129 hasConceptScore W4243010129C2778376644 @default.
• W4243010129 hasConceptScore W4243010129C2778721537 @default.
• W4243010129 hasConceptScore W4243010129C2779234561 @default.
• W4243010129 hasConceptScore W4243010129C2779252433 @default.
• W4243010129 hasConceptScore W4243010129C2779303187 @default.
• W4243010129 hasConceptScore W4243010129C2779918416 @default.
• W4243010129 hasConceptScore W4243010129C535046627 @default.
• W4243010129 hasConceptScore W4243010129C54355233 @default.
• W4243010129 hasConceptScore W4243010129C71924100 @default.
• W4243010129 hasConceptScore W4243010129C86803240 @default.
• W4243010129 hasLocation W42430101291 @default.
• W4243010129 hasLocation W42430101292 @default.
• W4243010129 hasOpenAccess W4243010129 @default.
• W4243010129 hasPrimaryLocation W42430101291 @default.
• W4243010129 hasRelatedWork W1783403169 @default.
• W4243010129 hasRelatedWork W1843212644 @default.
• W4243010129 hasRelatedWork W2363264463 @default.
• W4243010129 hasRelatedWork W2506208176 @default.
• W4243010129 hasRelatedWork W2706789201 @default.
• W4243010129 hasRelatedWork W3035259481 @default.
• W4243010129 hasRelatedWork W3165562685 @default.
• W4243010129 hasRelatedWork W4243010129 @default.
• W4243010129 hasRelatedWork W4245418057 @default.
• W4243010129 hasRelatedWork W825854623 @default.
• W4243010129 isParatext "false" @default.
• W4243010129 isRetracted "false" @default.
• W4243010129 workType "reference-entry" @default.