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- W4243081639 abstract "Cast your mind back to the 1980’s. The most prevalent theory then for the cause of MS was an infection, of which Epstein-Barr virus (EBV) was the lead contender. In the 1990’s rapid genome sequencing became available such that over the subsequent 20 years, discovery was made of numerous polymorphisms (normal variants) in several neurological conditions. Researchers in Parkinson’s disease had a field day, but sadly nothing emerged for MS; just polymorphisms that probably account for no more than 30% of the total disease risk. Thus, it could be argued that 70% of MS aetiology relates to environmental factors. The pendulum has now begun to swing back towards infection and the lead candidate remains EBV. Perhaps the single most troubling question for EBV involvement in MS is that given the majority of a population has been infected by EBV - why do only so few develop MS?" @default.
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- W4243081639 date "2017-08-01" @default.
- W4243081639 modified "2023-10-16" @default.
- W4243081639 title "Editors’ Welcome" @default.
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- W4243081639 doi "https://doi.org/10.1016/j.msard.2017.07.015" @default.
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