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- W4243125568 abstract "Plummer-Vinson syndrome is a fairly uncommon disease with triad of glossitis, dysphagia and angular erosion. Oral inflammatory lesions such as glossitis, angular stomatitis and other oral erosions are commonly observed in patients with this syndrome. However, the onset mechanism of oral lesions associated with Plummer-Vinson syndrome is still obscure. Iron deficiency is certaining important, but other factors may be also involved in the pathogenesis.This paper describes two cases of this syndrome and the neutrophilic function in the peripheral blood was examined for the purpose of elucidating its possible role in the formation of oral lesions.In the two patients, both females aged 67 and 47 respectively, a typical iron deficiency anemia was confirmed by routine hematology. Then tongues were markedly atrophic and are patient had spoon-shaped nails. Following the treatment with iron derivatives, they were much improved and abnormal findings almost disappeared. As for the neutrophilic functions, both phagocytizing and bactericidal power decreased prior to the Fe treatment. No change occurred in the phagocytizing power, although the bactericidal power was improved after the administration of Fe derivatives. In general, thinned or atrophied oral mucosa is said to be caused by iron deficiency in this syndrome, however, this does not necessarily contribute to the occurrence of inflammatory symptoms and other factors seen to the involved in this situation.Our results suggest that the depressed function of nuetrophil may be, in part at least, a causative factor of oral inflammatory lesions in Plummer-Vinson syndrome." @default.
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- W4243125568 date "1984-01-01" @default.
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- W4243125568 doi "https://doi.org/10.5794/jjoms.30.399" @default.
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