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- W4243130468 abstract "Abstract. This is a report of 63 episodes of agranulocytosis in 51 patients during a period of 18.5 years (1950–68). In 54 cases (93%) there was a positive history of drug ingestion, most of those without such history being from the period before 1959. An “idiopathic” case of agranulocytosis is almost entirely a function of inadequate history‐taking. The frequency of agranulocytosis has greatly increased during the period, the increment being entirely in women. During the years 1950–59 the ratio of men to women was 4: 11, in 1960–68 4: 44. The mortality has decreased from the 83% of 1950–54 to 13% in 1960–68, being close to zero for patients under 50 years of age and in adequate treatment. As causative agents, sulphonamides and aminophenazone were the most commonly observed, the estimated incidence for the latter being 1 per 40,000 cures of the drug. A history of the use of chloramphenicol was rather common, but always in combination with other drugs known to cause agranulocytosis. The next most common agents were carbimazole, phenylbutazone and thioridazine, occasional cases being attributed to carbutamide, mephenytoin, thiamazole, phenobarbital, barbital, amithiozole, thiocarlide, metamizol natrium, tetracycline, chlorothiazide and chlorpromazine." @default.
- W4243130468 created "2022-05-12" @default.
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- W4243130468 date "1970-01-12" @default.
- W4243130468 modified "2023-09-24" @default.
- W4243130468 title "DRUG‐INDUCED AGRANULOCYTOSIS, WITH SPECIAL REFERENCE TO AMINOPHENAZONE" @default.
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- W4243130468 doi "https://doi.org/10.1111/j.0954-6820.1970.tb02916.x" @default.
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